DegronMD

Uniprot ID: Q14149

Source protein: MORC family CW-type zinc finger protein 3

Source gene: MORC3

Class: DEG_SCF_FBW7_1

Location: 496:502

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 94.1143

COIL: 0.9507

CONS_SCORE: 0.5542

DSS_SCORE: 0.5337

HELIX: 0.0236

FCONS_SCORE: 1.0105

RIG_SCORE: 0.6346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N486H	TCGA-A5-A2K5	UCEC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	0.0556
p.N486H	DO41379	UCEC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	0.0556
p.S497L	TCGA-AX-A2HC	UCEC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	0.7667
p.S497L	DO41572	UCEC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	0.7667
p.A495T	TCGA-B7-A5TN	STAD	TCGA	LSTPSFS	DEG_SCF_FBW7_1	0.3056
p.A495T	DO222331	STAD	ICGC	LSTPSFS	DEG_SCF_FBW7_1	0.3056
p.R492Q	TCGA-CJ-6027	KIRC	TCGA	LSTPSFS	DEG_SCF_FBW7_1	0.2222
p.R492Q	DO18312	KIRC	ICGC	LSTPSFS	DEG_SCF_FBW7_1	0.2222
p.S502P	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LSTPSFS	DEG_SCF_FBW7_1	0.6752
p.S502P	ACH-000865	Esophageal Cancer	CCLE	LSTPSFS	DEG_SCF_FBW7_1	0.6752
p.S502P	KYSE-450	oesophagus	COSMIC	LSTPSFS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14149	MORC family CW-type zinc finger protein 3	DEG_SCF_FBW7_1	496:502	LSTPSFS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons