DegronMD

Uniprot ID: Q6PJT7

Source protein: Zinc finger CCCH domain-containing protein 14

Source gene: ZC3H14

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 84.56

COIL: 0.8612

CONS_SCORE: 0.3693

DSS_SCORE: 0.7168

HELIX: 0.1226

FCONS_SCORE: 1.0927

RIG_SCORE: 0.5922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N142D	TCGA-2Y-A9H7	LIHC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1389
p.N142D	DO219533	LIHC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1389
p.A122S	TCGA-93-8067	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.A122S	DO25113	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.S135L	TCGA-AP-A1E0	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	TCGA-AX-A05Z	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	TCGA-B5-A11N	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	TCGA-EO-A22U	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	TCGA-EO-A22X	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	DO40884	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	DO43154	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	DO43907	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	DO43755	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S135L	DO41458	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.A122E	TCGA-B0-4700	KIRC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.A122E	DO16961	KIRC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.Q136P	TCGA-L9-A443	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.3056
p.Q136P	DO24285	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	0.3056
p.P143Q	DO47407	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.E127V	DO229275	THCA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.2222
p.V126I	DO41235	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.6389
p.Q134K	DO41235	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.6944
p.R144I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.R144I	NCI-H2342	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.L144W	PA-1	ovary	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.V144I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.D133N	NCI-H650	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons