DegronMD - Q8NFU7(TET1)

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation (PubMed:19372391, PubMed:21496894). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC) (PubMed:21778364). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes and diseases, including stem cell maintenance, T and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Plays an essential role in the protection and maintenance of transcriptional and developmental programs together with QSER1 to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). {ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T563N	TCGA-13-1500	OV	TCGA	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1667
p.T563N	DO29698	OV	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1667
p.L517F	TCGA-66-2763	LUSC	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6981
p.L517F	DO27620	LUSC	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6981
p.P509L	TCGA-A6-A566	COAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.P509L	DO44092	COAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.S527L	TCGA-A8-A0A7	BRCA	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6556
p.S527L	TCGA-ZF-A9R7	BLCA	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6556
p.S527L	DO219064	BLCA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6556
p.S527L	DO5936	BRCA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6556
p.P581L	TCGA-AA-A01C	COAD	TCGA	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	TCGA-AX-A1CE	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	DO7781	COAD	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	DO228338	MALY	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	DO42280	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	SIDM00948	Burkitt's Lymphoma	GDSC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	ACH-002232	Lymphoma	CCLE	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.P581L	DG-75	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1111
p.E484D	TCGA-AN-A046	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.E484D	DO1285	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.T559A	TCGA-AP-A0LD	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.0556
p.T559A	DO41578	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.0556
p.S481P	TCGA-AU-6004	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.6752
p.S481P	DO7780	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.6752
p.Q467P	TCGA-AX-A05Z	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.Q467P	DO40884	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.S1824R	TCGA-BS-A0UF	UCEC	TCGA	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.S1824R	DO41488	UCEC	ICGC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.S1824I	TCGA-CV-7254	HNSC	TCGA	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.S1824I	DO14168	HNSC	ICGC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.A1837T	TCGA-D7-A4YV	STAD	TCGA	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.A1837T	DO47777	STAD	ICGC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.L583F	TCGA-D7-A6EZ	STAD	TCGA	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.0556
p.L583F	DO50119	STAD	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.0556
p.L523P	TCGA-DM-A28M	COAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6471
p.L523P	DO7942	COAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6471
p.P489H	TCGA-DU-6392	LGG	TCGA	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.P489H	DO22237	LGG	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.Q467H	TCGA-EO-A22X	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.Q467H	DO43907	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.S1832L	TCGA-IB-7651	PAAD	TCGA	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7667
p.S1832L	DO46657	PAAD	ICGC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7667
p.S1832L	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7667
p.S1832L	ACH-002264	Esophageal Cancer	CCLE	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7667
p.S1832L	KYSE-50	oesophagus	COSMIC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7667
p.A536D	TCGA-MP-A4T4	LUAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1667
p.A536D	DO45357	LUAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1667
p.S487T	DO234338	ESAD	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.V566L	DO229018	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.25
p.G529C	DO229009	LICA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6489
p.P519S	DO220864	MELA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation altering degron motif	0.6752
p.S487L	DO222721	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00570	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00584	Osteosarcoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM01175	Other Sarcomas	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00367	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00296	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00358	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM01653	Non-Cancerous	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00280	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00397	Acute Myeloid Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00207	Glioblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00381	Cervical Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00168	Head and Neck Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM01336	Glioblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.S487L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.L1833M	DO232224	PBCA	ICGC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.5999
p.H1839R	SIDM01951	Colorectal Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2222
p.A1837S	SIDM00985	Burkitt's Lymphoma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.A1837S	ACH-000245	Lymphoma	CCLE	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.A1837S	BL-41	haematopoietic and lymphoid tissue	COSMIC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation rewiring degron network	0.2778
p.S570G	SIDM01090	Colorectal Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation altering degron motif	0.5882
p.G474E	SIDM01041	Esophageal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.G474E	ACH-001500	Esophageal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.G474E	FLO-1	oesophagus	COSMIC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.M1834K	SIDM00650	Small Cell Lung Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.6951
p.M1834K	SIDM01681	Non-Cancerous	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.6951
p.P1835L	SIDM01148	Plasma Cell Myeloma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	SIDM00562	Breast Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	SIDM00561	Other Blood Cancers	GDSC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	ACH-002163	Breast Cancer	CCLE	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	ACH-002274	Leukemia	CCLE	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	MRK-nu-1	breast	COSMIC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P1835L	MLMA	haematopoietic and lymphoid tissue	COSMIC	DNTKTYSLMP	CBL_PTK	1826:1835	Mutation altering degron motif	0.7582
p.P509S	SIDM00596	Endometrial Carcinoma	GDSC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.P509S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.P509S	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.P509S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.P509S	HEC-1	endometrium	COSMIC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1111
p.G472D	SIDM00963	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.G472D	ACH-000927	Breast Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.G472D	BT-474	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.T512A	SIDM00785	Acute Myeloid Leukemia	GDSC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1944
p.T512A	ACH-000386	Leukemia	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1944
p.T512A	KG-1	haematopoietic and lymphoid tissue	COSMIC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	517:530	Mutation rewiring degron network	0.1944
p.S570N	ACH-002287	Colon/Colorectal Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation altering degron motif	0.5958
p.S570N	NCI-H630	large intestine	COSMIC	VSTSS	DEG_SPOP_SBC_1	569:573	Mutation altering degron motif	0.5958

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TET1

UniProt ID: Q8NFU7

Entrez ID: 80312

Protein name: Methylcytosine dioxygenase TET1 (EC 1.14.11.n2) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TET1 in