DegronMD

Uniprot ID: Q8NFU7

Source protein: Methylcytosine dioxygenase TET1

Source gene: TET1

Class: CBL_PTK

Location: 1826:1835

E3 ligase: CBL

DEGRON score: 0.5034

ASA_SCORE: 83.49

COIL: 0.8905

CONS_SCORE: 0.3641

DSS_SCORE: 0.5283

HELIX: 0.068

FCONS_SCORE: 1.0504

RIG_SCORE: 0.6881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1824R	TCGA-BS-A0UF	UCEC	TCGA	DNTKTYSLMP	CBL_PTK	0.2778
p.S1824R	DO41488	UCEC	ICGC	DNTKTYSLMP	CBL_PTK	0.2778
p.S1824I	TCGA-CV-7254	HNSC	TCGA	DNTKTYSLMP	CBL_PTK	0.2778
p.S1824I	DO14168	HNSC	ICGC	DNTKTYSLMP	CBL_PTK	0.2778
p.A1837T	TCGA-D7-A4YV	STAD	TCGA	DNTKTYSLMP	CBL_PTK	0.2778
p.A1837T	DO47777	STAD	ICGC	DNTKTYSLMP	CBL_PTK	0.2778
p.S1832L	TCGA-IB-7651	PAAD	TCGA	DNTKTYSLMP	CBL_PTK	0.7667
p.S1832L	DO46657	PAAD	ICGC	DNTKTYSLMP	CBL_PTK	0.7667
p.S1832L	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	0.7667
p.S1832L	ACH-002264	Esophageal Cancer	CCLE	DNTKTYSLMP	CBL_PTK	0.7667
p.S1832L	KYSE-50	oesophagus	COSMIC	DNTKTYSLMP	CBL_PTK	0.7667
p.L1833M	DO232224	PBCA	ICGC	DNTKTYSLMP	CBL_PTK	0.5999
p.H1839R	SIDM01951	Colorectal Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	0.2222
p.A1837S	SIDM00985	Burkitt's Lymphoma	GDSC	DNTKTYSLMP	CBL_PTK	0.2778
p.A1837S	ACH-000245	Lymphoma	CCLE	DNTKTYSLMP	CBL_PTK	0.2778
p.A1837S	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	DNTKTYSLMP	CBL_PTK	0.2778
p.M1834K	SIDM00650	Small Cell Lung Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	0.6951
p.M1834K	SIDM01681	Non-Cancerous	GDSC	DNTKTYSLMP	CBL_PTK	0.6951
p.P1835L	SIDM01148	Plasma Cell Myeloma	GDSC	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	SIDM00562	Breast Carcinoma	GDSC	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	SIDM00561	Other Blood Cancers	GDSC	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	ACH-002163	Breast Cancer	CCLE	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	ACH-002274	Leukemia	CCLE	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	MRK-nu-1	breast	COSMIC	DNTKTYSLMP	CBL_PTK	0.7582
p.P1835L	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	DNTKTYSLMP	CBL_PTK	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU7	Methylcytosine dioxygenase TET1	CBL_PTK	1826:1835	DNTKTYSLMP	CBL	0.5034	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DNTKTYSLMP

Degron related mutations and impact score

Drug responses associated with TET1 mutations

All proteins holding degron of DNTKTYSLMP