DegronMD

Uniprot ID: Q8NFU7

Source protein: Methylcytosine dioxygenase TET1

Source gene: TET1

Class: DEG_ODPH_VHL_1

Location: 517:530

E3 ligase: VHL

DEGRON score: 0.7055

ASA_SCORE: 74.0857

COIL: 0.7051

CONS_SCORE: 0.3044

DSS_SCORE: 0.3531

HELIX: 0.2344

FCONS_SCORE: 0.7822

RIG_SCORE: 0.7639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L517F	TCGA-66-2763	LUSC	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6981
p.L517F	DO27620	LUSC	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6981
p.P509L	TCGA-A6-A566	COAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.P509L	DO44092	COAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.S527L	TCGA-A8-A0A7	BRCA	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6556
p.S527L	TCGA-ZF-A9R7	BLCA	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6556
p.S527L	DO219064	BLCA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6556
p.S527L	DO5936	BRCA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6556
p.L523P	TCGA-DM-A28M	COAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6471
p.L523P	DO7942	COAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6471
p.A536D	TCGA-MP-A4T4	LUAD	TCGA	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1667
p.A536D	DO45357	LUAD	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1667
p.G529C	DO229009	LICA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6489
p.P519S	DO220864	MELA	ICGC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.6752
p.P509S	SIDM00596	Endometrial Carcinoma	GDSC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.P509S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.P509S	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.P509S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.P509S	HEC-1	endometrium	COSMIC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1111
p.T512A	SIDM00785	Acute Myeloid Leukemia	GDSC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1944
p.T512A	ACH-000386	Leukemia	CCLE	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1944
p.T512A	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPERGLFHASLGI	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_ODPH_VHL_1	517:530	LAPERGLFHASLGI	VHL	0.7055	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPERGLFHASLGI

Degron related mutations and impact score

Drug responses associated with TET1 mutations

All proteins holding degron of LAPERGLFHASLGI