DegronMD

Uniprot ID: Q8NFU7

Source protein: Methylcytosine dioxygenase TET1

Source gene: TET1

Class: DEG_SPOP_SBC_1

Location: 477:481

E3 ligase: SPOP

DEGRON score: 0.9239

ASA_SCORE: 71.96

COIL: 0.9118

CONS_SCORE: 0.3617

DSS_SCORE: 0.6719

HELIX: 0.0366

FCONS_SCORE: 1.1065

RIG_SCORE: 0.5773

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E484D	TCGA-AN-A046	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.E484D	DO1285	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.25
p.S481P	TCGA-AU-6004	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	0.6752
p.S481P	DO7780	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	0.6752
p.Q467P	TCGA-AX-A05Z	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.0556
p.Q467P	DO40884	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.0556
p.P489H	TCGA-DU-6392	LGG	TCGA	PQSSS	DEG_SPOP_SBC_1	0.1111
p.P489H	DO22237	LGG	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1111
p.Q467H	TCGA-EO-A22X	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.0556
p.Q467H	DO43907	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.0556
p.S487T	DO234338	ESAD	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	DO222721	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00570	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00584	Osteosarcoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM01175	Other Sarcomas	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00367	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00296	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00358	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM01653	Non-Cancerous	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00280	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00397	Acute Myeloid Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00207	Glioblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00381	Cervical Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00168	Head and Neck Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM01336	Glioblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S487L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.G474E	SIDM01041	Esophageal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.25
p.G474E	ACH-001500	Esophageal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	0.25
p.G474E	FLO-1	oesophagus	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.25
p.G472D	SIDM00963	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1944
p.G472D	ACH-000927	Breast Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	0.1944
p.G472D	BT-474	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	1117:1121	PQSSS	SPOP	0.9855	More...
O60271	C-Jun-amino-terminal kinase-interacting protein 4	DEG_SPOP_SBC_1	1239:1243	PQSSS	SPOP	0.9213	More...
O95409	Zinc finger protein ZIC 2	DEG_SPOP_SBC_1	447:451	PQSSS	SPOP	0.931	More...
O95835	Serine/threonine-protein kinase LATS1	DEG_SPOP_SBC_1	434:438	PQSSS	SPOP	0.9911	More...
O96013	Serine/threonine-protein kinase PAK 4	DEG_SPOP_SBC_1	240:244	PQSSS	SPOP	0.6645	More...
P0CB47	Upstream-binding factor 1-like protein 1	DEG_SPOP_SBC_1	325:329	PQSSS	SPOP	0.8335	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	249:253	PQSSS	SPOP	0.9306	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	60:64	PQSSS	SPOP	0.674	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	1582:1586	PQSSS	SPOP	0.989	More...
P49023	Paxillin	DEG_SPOP_SBC_1	81:85	PQSSS	SPOP	0.9894	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	138:142	PQSSS	SPOP	0.9993	More...
Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	DEG_SPOP_SBC_1	887:891	PQSSS	SPOP	0.997	More...
Q2TAZ0	Autophagy-related protein 2 homolog A	DEG_SPOP_SBC_1	742:746	PQSSS	SPOP	0.9683	More...
Q5TCM9	Late cornified envelope protein 5A	DEG_SPOP_SBC_1	82:86	PQSSS	SPOP	0.798	More...
Q6UY09	Carcinoembryonic antigen-related cell adhesion molecule 20	DEG_SPOP_SBC_1	438:442	PQSSS	SPOP	0.8914	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	299:303	PQSSS	SPOP	0.8349	More...
Q8NCP5	Zinc finger and BTB domain-containing protein 44	DEG_SPOP_SBC_1	334:338	PQSSS	SPOP	0.902	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	477:481	PQSSS	SPOP	0.9239	More...
Q8NHY3	GAS2-like protein 2	DEG_SPOP_SBC_1	384:388	PQSSS	SPOP	0.9783	More...
Q8TDM6	Disks large homolog 5	DEG_SPOP_SBC_1	797:801	PQSSS	SPOP	0.9776	More...
Q8WXI9	Transcriptional repressor p66-beta	DEG_SPOP_SBC_1	300:304	PQSSS	SPOP	0.9946	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	519:523	PQSSS	SPOP	0.9325	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	99:103	PQSSS	SPOP	0.9292	More...
Q9BWV1	Brother of CDO	DEG_SPOP_SBC_1	592:596	PQSSS	SPOP	0.7123	More...
Q9H5V7	Zinc finger protein Pegasus	DEG_SPOP_SBC_1	305:309	PQSSS	SPOP	0.6593	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	322:326	PQSSS	SPOP	0.9692	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	739:743	PQSSS	SPOP	0.9901	More...
Q9UNW9	RNA-binding protein Nova-2	DEG_SPOP_SBC_1	204:208	PQSSS	SPOP	0.9633	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	413:417	PQSSS	SPOP	0.9895	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	83:87	PQSSS	SPOP	0.8965	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	129:133	PQSSS	SPOP	0.9781	More...
F5H4B4	Protein FAM227A	DEG_SPOP_SBC_1	345:349	PQSSS	SPOP	0.9381	More...
P0CB48	Putative upstream-binding factor 1-like protein 6	DEG_SPOP_SBC_1	332:336	PQSSS	SPOP	0.5892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSSS

Degron related mutations and impact score

Drug responses associated with TET1 mutations

All proteins holding degron of PQSSS