DegronMD - Q8WYB5(KAT6B)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1759S	TCGA-2W-A8YY	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation altering degron motif	0.6752
p.P1276S	TCGA-75-6214	LUAD	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.6752
p.R1052Q	TCGA-90-A4ED	LUSC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1944
p.R1052Q	SIDM01617	Endometrial Carcinoma	GDSC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1944
p.R1052Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1944
p.P1276Q	TCGA-A3-A6NL	KIRC	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.7035
p.L1273S	TCGA-A5-A0G2	UCEC	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.7667
p.P1283S	TCGA-A5-A0G2	UCEC	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.2222
p.R1052W	TCGA-A5-A1OF	UCEC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1944
p.S1761N	TCGA-BC-A69H	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation altering degron motif	0.7069
p.P1760L	TCGA-BR-8078	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation altering degron motif	0.6471
p.H1047Y	TCGA-BS-A0UM	UCEC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.0556
p.P1049Q	TCGA-CR-7402	HNSC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1111
p.P1276T	TCGA-DA-A1IB	SKCM	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.7031
p.S510F	TCGA-EE-A29D	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0833
p.S510F	DO38123	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0833
p.S523F	TCGA-ER-A19M	SKCM	TCGA	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.6871
p.S523F	TCGA-ER-A19M	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7982
p.S523F	DO37798	SKCM	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.6871
p.S523F	DO37798	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7982
p.P1280L	TCGA-FR-A726	SKCM	TCGA	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.3056
p.P1049T	TCGA-FS-A1ZG	SKCM	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1111
p.P519L	TCGA-FW-A3R5	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.P519L	DO37406	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.7582
p.C1769Y	TCGA-WN-AB4C	KIRP	TCGA	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1667
p.Y526C	DO469	BLCA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.7087
p.E1059Q	DO2216	BRCA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation altering degron motif	0.6744
p.G1752S	DO9756	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.E530G	DO223082	ESCA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.7199
p.A1286V	DO233109	GACA	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.1389
p.T1284S	DO228299	LICA	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.1944
p.C509F	DO229019	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation substituting flanking lysine	0.1667
p.C509F	DO229038	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation substituting flanking lysine	0.1667
p.Q1772H	DO229029	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.0833
p.G1048V	DO229028	LICA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation blocking phosphorylation signal	0.5278
p.A513S	DO229027	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation rewiring degron network	0.1111
p.A513S	DO229027	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.V536F	DO229037	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation rewiring degron network	0.1944
p.P517S	DO229051	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation rewiring degron network	0.2222
p.P517S	DO229051	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.S524I	DO229008	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.7341
p.Q520H	DO231179	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.647
p.F534L	DO52686	MALY	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation rewiring degron network	0.25
p.E1272Q	DO220900	MELA	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.3056
p.E1067K	DO222402	MELA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.2778
p.D1287N	DO227506	ORCA	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.1111
p.Q1268H	DO27982	OV	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.1944
p.E530K	DO46657	PAAD	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.7022
p.D1269E	DO232761	PBCA	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.2222
p.G1752C	DO37961	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.P531S	DO38727	STAD	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.6752
p.H1761Y	DO51761	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation altering degron motif	0.7229
p.T524M	DO42608	UCEC	ICGC	SSSSQCSVPSL	DEG_COP1_1	521:531	Mutation altering degron motif	0.7423
p.C1277G	DO41488	UCEC	ICGC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.76
p.Q520L	SIDM02040	Esophageal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.6654
p.S1770G	SIDM01169	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.S1770G	ACH-000885	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.S1770G	TOV-21G	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.Y1274C	SIDM01045	Endometrial Carcinoma	GDSC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.5976
p.Y1274C	ACH-000978	Endometrial/Uterine Cancer	CCLE	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.5976
p.Y1274C	EN	endometrium	COSMIC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation altering degron motif	0.5976
p.K1067N	HCT-15	large intestine	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.2778
p.G1752A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.G1752A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	1759:1763	Mutation rewiring degron network	0.1389
p.A1271V	LS-411N	large intestine	COSMIC	LYTPPET	DEG_SCF_FBW7_1	1273:1279	Mutation rewiring degron network	0.2778
p.P1058H	CAL-51	breast	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation altering degron motif	0.7694
p.K1060R	KP-3	pancreas	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	1057:1065	Mutation altering degron motif	0.7237

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KAT6B

UniProt ID: Q8WYB5

Entrez ID: 23522

Protein name: Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KAT6B in