DegronMD

Uniprot ID: Q8WYB5

Source protein: Histone acetyltransferase KAT6B

Source gene: KAT6B

Class: DEG_APCC_DBOX_1

Location: 1057:1065

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9471

ASA_SCORE: 98.3556

COIL: 0.6399

CONS_SCORE: 0.4158

DSS_SCORE: 0.7889

HELIX: 0.3229

FCONS_SCORE: 1.049

RIG_SCORE: 0.6259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1052Q	TCGA-90-A4ED	LUSC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	0.1944
p.R1052Q	SIDM01617	Endometrial Carcinoma	GDSC	ERGQLLELS	DEG_APCC_DBOX_1	0.1944
p.R1052Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	ERGQLLELS	DEG_APCC_DBOX_1	0.1944
p.R1052W	TCGA-A5-A1OF	UCEC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	0.1944
p.H1047Y	TCGA-BS-A0UM	UCEC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	0.0556
p.P1049Q	TCGA-CR-7402	HNSC	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	0.1111
p.P1049T	TCGA-FS-A1ZG	SKCM	TCGA	ERGQLLELS	DEG_APCC_DBOX_1	0.1111
p.E1059Q	DO2216	BRCA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	0.6744
p.G1048V	DO229028	LICA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	0.5278
p.E1067K	DO222402	MELA	ICGC	ERGQLLELS	DEG_APCC_DBOX_1	0.2778
p.K1067N	HCT-15	large_intestine	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	0.2778
p.P1058H	CAL-51	breast	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	0.7694
p.K1060R	KP-3	pancreas	COSMIC	ERGQLLELS	DEG_APCC_DBOX_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYB5	Histone acetyltransferase KAT6B	DEG_APCC_DBOX_1	1057:1065	ERGQLLELS	APC,CDC20,FZR1	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons