DegronMD

Uniprot ID: Q8WYB5

Source protein: Histone acetyltransferase KAT6B

Source gene: KAT6B

Class: DEG_SCF_FBW7_1

Location: 1273:1279

E3 ligase: FBXW7

DEGRON score: 0.9962

ASA_SCORE: 101.6571

COIL: 0.9423

CONS_SCORE: 0.4736

DSS_SCORE: 0.6625

HELIX: 0.0226

FCONS_SCORE: 1.1191

RIG_SCORE: 0.6802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1276S	TCGA-75-6214	LUAD	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.6752
p.P1276Q	TCGA-A3-A6NL	KIRC	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.7035
p.L1273S	TCGA-A5-A0G2	UCEC	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.7667
p.P1283S	TCGA-A5-A0G2	UCEC	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.2222
p.P1276T	TCGA-DA-A1IB	SKCM	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.7031
p.P1280L	TCGA-FR-A726	SKCM	TCGA	LYTPPET	DEG_SCF_FBW7_1	0.3056
p.A1286V	DO233109	GACA	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.1389
p.T1284S	DO228299	LICA	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.1944
p.E1272Q	DO220900	MELA	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.3056
p.D1287N	DO227506	ORCA	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.1111
p.Q1268H	DO27982	OV	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.1944
p.D1269E	DO232761	PBCA	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.2222
p.C1277G	DO41488	UCEC	ICGC	LYTPPET	DEG_SCF_FBW7_1	0.76
p.Y1274C	SIDM01045	Endometrial Carcinoma	GDSC	LYTPPET	DEG_SCF_FBW7_1	0.5976
p.Y1274C	ACH-000978	Endometrial/Uterine Cancer	CCLE	LYTPPET	DEG_SCF_FBW7_1	0.5976
p.Y1274C	EN	endometrium	COSMIC	LYTPPET	DEG_SCF_FBW7_1	0.5976
p.A1271V	LS-411N	large_intestine	COSMIC	LYTPPET	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SCF_FBW7_1	1273:1279	LYTPPET	FBXW7	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons