DegronMD

Uniprot ID: Q8WYB5

Source protein: Histone acetyltransferase KAT6B

Source gene: KAT6B

Class: DEG_COP1_1

Location: 521:531

E3 ligase: COP1

DEGRON score: 0.969

ASA_SCORE: 75.0364

COIL: 0.8596

CONS_SCORE: 0.1332

DSS_SCORE: 0.5647

HELIX: 0.1044

FCONS_SCORE: 0.8698

RIG_SCORE: 0.5935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S523F	TCGA-ER-A19M	SKCM	TCGA	SSSSQCSVPSL	DEG_COP1_1	0.6871
p.S523F	DO37798	SKCM	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.6871
p.Y526C	DO469	BLCA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.7087
p.E530G	DO223082	ESCA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.7199
p.A513S	DO229027	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.1111
p.V536F	DO229037	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.1944
p.P517S	DO229051	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.2222
p.S524I	DO229008	LICA	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.7341
p.F534L	DO52686	MALY	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.25
p.E530K	DO46657	PAAD	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.7022
p.P531S	DO38727	STAD	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.6752
p.T524M	DO42608	UCEC	ICGC	SSSSQCSVPSL	DEG_COP1_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYB5	Histone acetyltransferase KAT6B	DEG_COP1_1	521:531	SSSSQCSVPSL	COP1	0.969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons