DegronMD - Q9BSD3(RHNO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P127S	TCGA-19-1787	GBM	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5641
p.P127S	DO13522	GBM	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5641
p.G138V	TCGA-43-5668	LUSC	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.G138V	DO26608	LUSC	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1667
p.P134S	TCGA-A5-A0G2	UCEC	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.P134S	DO41235	UCEC	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778
p.S181R	TCGA-AN-A046	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.S181R	DO1285	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.S181N	TCGA-AP-A059	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.S181N	DO41361	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.E168K	TCGA-AP-A1DV	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.1667
p.E168K	TCGA-AP-A1DV	UCEC	TCGA	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1944
p.E168K	TCGA-AP-A1DV	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.E168K	DO43186	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.1667
p.E168K	DO43186	UCEC	ICGC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1944
p.E168K	DO43186	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.E168K	SIDM01045	Endometrial Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.1667
p.E168K	SIDM01045	Endometrial Carcinoma	GDSC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1944
p.E168K	SIDM01045	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.E168K	ACH-000978	Endometrial/Uterine Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.1667
p.E168K	ACH-000978	Endometrial/Uterine Cancer	CCLE	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1944
p.E168K	ACH-000978	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.E168K	EN	endometrium	COSMIC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.1667
p.E168K	EN	endometrium	COSMIC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1944
p.E168K	EN	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.P171L	TCGA-DU-6407	LGG	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.P171L	TCGA-DU-6407	LGG	TCGA	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.P171L	TCGA-DU-6407	LGG	TCGA	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1389
p.P171L	TCGA-EE-A29D	SKCM	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.P171L	TCGA-EE-A29D	SKCM	TCGA	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.P171L	TCGA-EE-A29D	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1389
p.P171L	DO22295	LGG	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.P171L	DO22295	LGG	ICGC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.P171L	DO22295	LGG	ICGC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1389
p.P171L	DO38123	SKCM	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation rewiring degron network	0.25
p.P171L	DO38123	SKCM	ICGC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.1111
p.P171L	DO38123	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1389
p.G108W	TCGA-EE-A3AG	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.G108W	DO37471	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1944
p.E176K	TCGA-EO-A22U	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation altering degron motif	0.7022
p.E176K	DO43755	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	174:178	Mutation altering degron motif	0.7022
p.S101P	TCGA-EO-A3AZ	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6752
p.S101P	DO50078	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6752
p.S104L	TCGA-G2-A2EO	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.3056
p.S104L	DO456	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.3056
p.R113Q	TCGA-VQ-A8PZ	STAD	TCGA	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.R113Q	DO51780	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.S162A	DO225348	BRCA	ICGC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation altering degron motif	0.6477
p.S162A	DO225348	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.7588
p.E97V	DO225357	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.L107F	DO228974	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.C115F	DO229009	LICA	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.S119L	DO220877	MELA	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1944
p.P99S	DO222396	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6752
p.S136R	SIDM00340	Plasma Cell Myeloma	GDSC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.S136R	ACH-000204	Myeloma	CCLE	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.S136R	LP-1	haematopoietic and lymphoid tissue	COSMIC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.L132R	SIDM00632	Non-Cancerous	GDSC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7316
p.H93Y	SIDM00359	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.H93Y	ACH-000565	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.H93Y	RCM-1	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.L107V	SIDM01611	Endometrial Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.L107V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.E154K	EN	endometrium	COSMIC	IQTPESS	DEG_SCF_FBW7_1	157:163	Mutation rewiring degron network	0.25
p.E154K	EN	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1667
p.S122R	LP-1	haematopoietic and lymphoid tissue	COSMIC	SRRPLVPVL	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHNO1

UniProt ID: Q9BSD3

Entrez ID: 83695

Protein name: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHNO1 in