DegronMD

Uniprot ID: Q9BSD3

Source protein: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Source gene: RHNO1

Class: DEG_APCC_KENBOX_2

Location: 174:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6857

ASA_SCORE: 99.88

COIL: 0.665

CONS_SCORE: 0.3713

DSS_SCORE: 0.568

HELIX: 0.3154

FCONS_SCORE: 0.8942

RIG_SCORE: 0.6959

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S181R	TCGA-AN-A046	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	0.25
p.S181R	DO1285	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.25
p.S181N	TCGA-AP-A059	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.25
p.S181N	DO41361	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.25
p.E168K	TCGA-AP-A1DV	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.1667
p.E168K	DO43186	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.1667
p.E168K	SIDM01045	Endometrial Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.1667
p.E168K	ACH-000978	Endometrial/Uterine Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	0.1667
p.E168K	EN	endometrium	COSMIC	QKENS	DEG_APCC_KENBOX_2	0.1667
p.P171L	TCGA-DU-6407	LGG	TCGA	QKENS	DEG_APCC_KENBOX_2	0.25
p.P171L	TCGA-EE-A29D	SKCM	TCGA	QKENS	DEG_APCC_KENBOX_2	0.25
p.P171L	DO22295	LGG	ICGC	QKENS	DEG_APCC_KENBOX_2	0.25
p.P171L	DO38123	SKCM	ICGC	QKENS	DEG_APCC_KENBOX_2	0.25
p.E176K	TCGA-EO-A22U	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.7022
p.E176K	DO43755	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14745	Na	DEG_APCC_KENBOX_2	265:269	QKENS	APC,CDC20,FZR1	0.9808	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_APCC_KENBOX_2	726:730	QKENS	APC,CDC20,FZR1	0.6976	More...
Q96GD4	Aurora kinase B	DEG_APCC_KENBOX_2	3:7	QKENS	APC,CDC20,FZR1	0.9973	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_APCC_KENBOX_2	174:178	QKENS	APC,CDC20,FZR1	0.6857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons