DegronMD

Uniprot ID: O14745

Source protein: Na

Source gene: SLC9A3R1

Class: DEG_APCC_KENBOX_2

Location: 265:269

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9808

ASA_SCORE: 106.5

COIL: 0.6188

CONS_SCORE: 0.478

DSS_SCORE: 0.5447

HELIX: 0.3708

FCONS_SCORE: 0.988

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P258T	TCGA-06-1087	GBM	TCGA	QKENS	DEG_APCC_KENBOX_2	0.1389
p.P258T	DO11549	GBM	ICGC	QKENS	DEG_APCC_KENBOX_2	0.1389
p.E263D	TCGA-A5-A0G2	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.2778
p.E263D	DO41235	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.2778
p.P256S	TCGA-AP-A1DK	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.0833
p.P256S	DO42033	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.0833
p.N261S	TCGA-BS-A0V8	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.2222
p.N261S	DO42240	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.2222
p.G262W	DO229026	LICA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.25
p.L273P	DO45299	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	0.2222
p.R270C	SIDM01293	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.3056
p.R270G	ACH-000669	Lung Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14745	Na	DEG_APCC_KENBOX_2	265:269	QKENS	APC,CDC20,FZR1	0.9808	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_APCC_KENBOX_2	726:730	QKENS	APC,CDC20,FZR1	0.6976	More...
Q96GD4	Aurora kinase B	DEG_APCC_KENBOX_2	3:7	QKENS	APC,CDC20,FZR1	0.9973	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_APCC_KENBOX_2	174:178	QKENS	APC,CDC20,FZR1	0.6857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons