DegronMD - O14745(SLC9A3R1)

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cellular phosphate ion homeostasis [GO:0030643]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sodium:proton antiporter activity [GO:0032416]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of ion transmembrane transport [GO:0034767]; protein-containing complex assembly [GO:0065003]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; regulation of sodium:proton antiporter activity [GO:0032415]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P258T	TCGA-06-1087	GBM	TCGA	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.1389
p.P258T	DO11549	GBM	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.1389
p.E263D	TCGA-A5-A0G2	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.2778
p.E263D	DO41235	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.2778
p.P256S	TCGA-AP-A1DK	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.0833
p.P256S	DO42033	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.0833
p.P152S	TCGA-AX-A0J1	UCEC	TCGA	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.5641
p.P152S	DO41199	UCEC	ICGC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.5641
p.N261S	TCGA-BS-A0V8	UCEC	TCGA	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.2222
p.N261S	DO42240	UCEC	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.2222
p.G30W	TCGA-D3-A2JO	SKCM	TCGA	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6714
p.G30W	DO228952	LICA	ICGC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6714
p.G30W	DO47619	SKCM	ICGC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6714
p.R180W	TCGA-EO-A22U	UCEC	TCGA	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.R180W	DO43755	UCEC	ICGC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.R180W	SIDM00146	Breast Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.R180W	SIDM00794	Other Solid Cancers	GDSC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.R180W	A388	skin	COSMIC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.R180W	MDA-MB-231	breast	COSMIC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.0833
p.P304R	TCGA-L5-A8NI	ESCA	TCGA	APSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1667
p.G176A	TCGA-L5-A8NM	ESCA	TCGA	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation rewiring degron network	0.1944
p.G262W	DO229026	LICA	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.25
p.R151L	DO229038	LICA	ICGC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.8428
p.L273P	DO45299	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.2222
p.G25D	DO52692	MALY	ICGC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.3056
p.F26S	DO42673	UCEC	ICGC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.7982
p.R270C	SIDM01293	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.3056
p.L150F	SIDM02034	Colorectal Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.587
p.R153Q	SIDM00422	Hodgkin's Lymphoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM00908	Non-Cancerous	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM00852	Glioma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM00542	Glioblastoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM00909	Melanoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM00519	Mesothelioma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM01560	Rhabdomyosarcoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R153Q	SIDM01709	Melanoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6218
p.R151W	SIDM01248	Thyroid Gland Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.8634
p.R151W	SIDM01167	Thyroid Gland Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.8634
p.R151W	CGTH-W-1	thyroid	COSMIC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.8634
p.D301V	SIDM00947	Glioblastoma	GDSC	APSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.D301V	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.D301V	SIDM00044	Head and Neck Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.T314A	SIDM00660	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7139
p.T314A	ACH-000985	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7139
p.T314A	LS-411N	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7139
p.R148H	SIDM01472	Hepatocellular Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.2778
p.H29R	ACH-000559	Lung Cancer	CCLE	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.8244
p.R270G	ACH-000669	Lung Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	265:269	Mutation rewiring degron network	0.3056
p.H144Y	ACH-001970	Metastasis	CCLE	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.1667
p.E33K	KYSE-510	oesophagus	COSMIC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.R24W	A388	skin	COSMIC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.R24W	MDA-MB-231	breast	COSMIC	FHLHGE	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.2778
p.A172T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	FNLHSD	LIG_APCC_ABBA_1	166:171	Mutation blocking ubiquitination signal	0.75
p.T158A	LS-411N	large intestine	COSMIC	LRPRLCTMK	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7139

Kaplan plot for SLC9A3R1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A3R1

UniProt ID: O14745

Entrez ID: 9368

Protein name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A3R1 in