DegronMD

Uniprot ID: O14745

Source protein: Na

Source gene: SLC9A3R1

Class: LIG_APCC_ABBA_1

Location: 166:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.818

ASA_SCORE: 30.5167

COIL: 0.4497

CONS_SCORE: 0.7966

DSS_SCORE: 0.6163

HELIX: 0.0262

FCONS_SCORE: 1.1817

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R180W	TCGA-EO-A22U	UCEC	TCGA	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.R180W	DO43755	UCEC	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.R180W	SIDM00146	Breast Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.R180W	SIDM00794	Other Solid Cancers	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.R180W	A388	skin	COSMIC	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.R180W	MDA-MB-231	breast	COSMIC	FNLHSD	LIG_APCC_ABBA_1	0.0833
p.G176A	TCGA-L5-A8NM	ESCA	TCGA	FNLHSD	LIG_APCC_ABBA_1	0.1944
p.A172T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FNLHSD	LIG_APCC_ABBA_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons