DegronMD

Uniprot ID: Q15599

Source protein: Na

Source gene: SLC9A3R2

Class: LIG_APCC_ABBA_1

Location: 163:168

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6766

ASA_SCORE: 30

COIL: 0.4282

CONS_SCORE: 0.5444

DSS_SCORE: 0.6062

HELIX: 0.0225

FCONS_SCORE: 1.1228

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q159R	TCGA-BR-4361	STAD	TCGA	FNLHSD	LIG_APCC_ABBA_1	0.2222
p.R171Q	TCGA-KK-A59V	PRAD	TCGA	FNLHSD	LIG_APCC_ABBA_1	0.25
p.N164S	TCGA-QC-A7B5	SARC	TCGA	FNLHSD	LIG_APCC_ABBA_1	0.5958
p.S169F	DO219049	BLCA	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.75
p.A159V	DO50220	LGG	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.2222
p.D170Y	DO228900	LICA	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.2778
p.G168C	DO229025	LICA	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.76
p.S158F	DO41193	UCEC	ICGC	FNLHSD	LIG_APCC_ABBA_1	0.1944
p.R171W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.25
p.R171W	SIDM00857	Melanoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.25
p.R171W	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.25
p.R171W	SIDM00638	Cervical Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.25
p.R171W	SIDM00701	Non-Cancerous	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.25
p.D168V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.7785
p.P172S	SIDM00760	Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.2222
p.P172S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.2222
p.P172S	SIDM01525	Acute Myeloid Leukemia	GDSC	FNLHSD	LIG_APCC_ABBA_1	0.2222
p.S177G	SNU-1040	large_intestine	COSMIC	FNLHSD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons