DegronMD - Q15599(SLC9A3R2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R238Q	TCGA-A5-A0G1	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.3056
p.R238Q	DO42472	UCEC	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.3056
p.Q159R	TCGA-BR-4361	STAD	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2222
p.Q159R	TCGA-BR-4361	STAD	TCGA	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2222
p.D229N	TCGA-CK-4951	COAD	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0556
p.D229N	DO10582	COAD	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0556
p.R150W	TCGA-CV-5436	HNSC	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.7523
p.V256I	TCGA-D1-A167	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0556
p.V256I	DO40978	UCEC	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0556
p.V256I	SIDM01753	Gastric Carcinoma	GDSC	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0556
p.V140I	TCGA-DD-AADR	LIHC	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1389
p.R145M	TCGA-EE-A2GN	SKCM	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.P230H	TCGA-EE-A3AE	SKCM	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation rewiring degron network	0.0833
p.R240W	TCGA-EO-A3B0	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation altering degron motif	0.7523
p.P243H	TCGA-EY-A5W2	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation altering degron motif	0.7694
p.R171Q	TCGA-KK-A59V	PRAD	TCGA	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.N164S	TCGA-QC-A7B5	SARC	TCGA	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation altering degron motif	0.5958
p.S169F	DO219049	BLCA	ICGC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation blocking ubiquitination signal	0.75
p.R37P	DO561	BLCA	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833
p.L6I	DO223931	BRCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.L6I	DO41361	UCEC	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.R4Q	DO223732	CESC	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.N155S	DO52707	CLLE	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.7069
p.G23D	DO7780	COAD	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.7198
p.E5G	DO50442	ESAD	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.V137M	DO233764	GACA	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation substituting flanking lysine	0.1667
p.A159V	DO50220	LGG	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2222
p.A159V	DO50220	LGG	ICGC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2222
p.D170Y	DO228900	LICA	ICGC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2778
p.A29S	DO229028	LICA	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.G168C	DO229025	LICA	ICGC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation altering degron motif	0.76
p.S141G	DO229050	LICA	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation blocking phosphorylation signal	0.6111
p.V29I	DO52245	LIHC	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.V26G	DO27785	MALY	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.7532
p.G5R	DO49168	PACA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.R34M	DO37896	SKCM	ICGC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1667
p.A2V	DO229211	THCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation substituting flanking lysine	0.3056
p.P12H	DO231286	THCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7694
p.S158F	DO41193	UCEC	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.25
p.S158F	DO41193	UCEC	ICGC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.1944
p.R171W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.R171W	SIDM00857	Melanoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.R171W	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.R171W	SIDM00638	Cervical Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.R171W	SIDM00701	Non-Cancerous	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.25
p.D168V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation altering degron motif	0.7785
p.R148H	SIDM00217	Colorectal Carcinoma	GDSC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8244
p.R148H	SNU-1040	large intestine	COSMIC	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.8244
p.P172S	SIDM00760	Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2222
p.P172S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2222
p.P172S	SIDM01525	Acute Myeloid Leukemia	GDSC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.2222
p.K137R	ACH-000448	Lung Cancer	CCLE	LRPRLCHLR	DEG_APCC_DBOX_1	147:155	Mutation substituting flanking lysine	0.1667
p.E28G	ACH-000463	Lung Cancer	CCLE	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.7199
p.R240Q	ACH-001651	Endometrial/Uterine Cancer	CCLE	LRVTPTEE	DEG_SCF_FBW7_2	239:246	Mutation altering degron motif	0.6218
p.S177G	SNU-1040	large intestine	COSMIC	FNLHSD	LIG_APCC_ABBA_1	163:168	Mutation rewiring degron network	0.0833
p.R37H	SNU-1040	large intestine	COSMIC	FHLHGE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0833

Kaplan plot for SLC9A3R2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A3R2

UniProt ID: Q15599

Entrez ID: 9351

Protein name: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A3R2 in