DegronMD

Uniprot ID: Q15599

Source protein: Na

Source gene: SLC9A3R2

Class: DEG_APCC_DBOX_1

Location: 7:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8239

ASA_SCORE: 55.5778

COIL: 0.3356

CONS_SCORE: 0.5492

DSS_SCORE: 0.4111

HELIX: 0.0031

FCONS_SCORE: 0.9351

RIG_SCORE: 0.8006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L6I	DO223931	BRCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.3056
p.L6I	DO41361	UCEC	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.3056
p.R4Q	DO223732	CESC	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.25
p.E5G	DO50442	ESAD	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.2778
p.G5R	DO49168	PACA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.2778
p.A2V	DO229211	THCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.3056
p.P12H	DO231286	THCA	ICGC	LRPRLCRLV	DEG_APCC_DBOX_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15599	Na	DEG_APCC_DBOX_1	7:15	LRPRLCRLV	APC,CDC20,FZR1	0.8239	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons