DegronMD

Uniprot ID: Q15599

Source protein: Na

Source gene: SLC9A3R2

Class: LIG_APCC_ABBA_1

Location: 23:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6763

ASA_SCORE: 33.7333

COIL: 0.2377

CONS_SCORE: 0.7962

DSS_SCORE: 0.4498

HELIX: 0.0047

FCONS_SCORE: 1.3706

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R37P	DO561	BLCA	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.0833
p.G23D	DO7780	COAD	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.7198
p.A29S	DO229028	LICA	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.3056
p.V29I	DO52245	LIHC	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.3056
p.V26G	DO27785	MALY	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.7532
p.R34M	DO37896	SKCM	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.1667
p.E28G	ACH-000463	Lung Cancer	CCLE	FHLHGE	LIG_APCC_ABBA_1	0.7199
p.R37H	SNU-1040	large_intestine	COSMIC	FHLHGE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons