DegronMD

Uniprot ID: O14745

Source protein: Na

Source gene: SLC9A3R1

Class: LIG_APCC_ABBA_1

Location: 26:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6167

ASA_SCORE: 33.6333

COIL: 0.2817

CONS_SCORE: 0.8706

DSS_SCORE: 0.3076

HELIX: 0.0115

FCONS_SCORE: 1.2003

RIG_SCORE: 0.7495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G30W	TCGA-D3-A2JO	SKCM	TCGA	FHLHGE	LIG_APCC_ABBA_1	0.6714
p.G30W	DO228952	LICA	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.6714
p.G30W	DO47619	SKCM	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.6714
p.G25D	DO52692	MALY	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.3056
p.F26S	DO42673	UCEC	ICGC	FHLHGE	LIG_APCC_ABBA_1	0.7982
p.H29R	ACH-000559	Lung Cancer	CCLE	FHLHGE	LIG_APCC_ABBA_1	0.8244
p.E33K	KYSE-510	oesophagus	COSMIC	FHLHGE	LIG_APCC_ABBA_1	0.2778
p.R24W	A388	skin	COSMIC	FHLHGE	LIG_APCC_ABBA_1	0.2778
p.R24W	MDA-MB-231	breast	COSMIC	FHLHGE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons