DegronMD

Uniprot ID: Q15599

Source protein: Na

Source gene: SLC9A3R2

Class: DEG_APCC_DBOX_1

Location: 147:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8484

ASA_SCORE: 50.6333

COIL: 0.3327

CONS_SCORE: 0.5443

DSS_SCORE: 0.5261

HELIX: 0.0152

FCONS_SCORE: 1.204

RIG_SCORE: 0.7668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q159R	TCGA-BR-4361	STAD	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	0.2222
p.R150W	TCGA-CV-5436	HNSC	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	0.7523
p.V140I	TCGA-DD-AADR	LIHC	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	0.1389
p.R145M	TCGA-EE-A2GN	SKCM	TCGA	LRPRLCHLR	DEG_APCC_DBOX_1	0.2778
p.N155S	DO52707	CLLE	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	0.7069
p.V137M	DO233764	GACA	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	0.1667
p.A159V	DO50220	LGG	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	0.2222
p.S141G	DO229050	LICA	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	0.6111
p.S158F	DO41193	UCEC	ICGC	LRPRLCHLR	DEG_APCC_DBOX_1	0.25
p.R148H	SIDM00217	Colorectal Carcinoma	GDSC	LRPRLCHLR	DEG_APCC_DBOX_1	0.8244
p.R148H	SNU-1040	large_intestine	COSMIC	LRPRLCHLR	DEG_APCC_DBOX_1	0.8244
p.K137R	ACH-000448	Lung Cancer	CCLE	LRPRLCHLR	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15599	Na	DEG_APCC_DBOX_1	147:155	LRPRLCHLR	APC,CDC20,FZR1	0.8484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons