DegronMD

Uniprot ID: Q15599

Source protein: Na

Source gene: SLC9A3R2

Class: DEG_SCF_FBW7_2

Location: 239:246

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 86.925

COIL: 0.7735

CONS_SCORE: 0.481

DSS_SCORE: 0.6086

HELIX: 0.2055

FCONS_SCORE: 0.9998

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R238Q	TCGA-A5-A0G1	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.3056
p.R238Q	DO42472	UCEC	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	0.3056
p.D229N	TCGA-CK-4951	COAD	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.0556
p.D229N	DO10582	COAD	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	0.0556
p.V256I	TCGA-D1-A167	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.0556
p.V256I	DO40978	UCEC	ICGC	LRVTPTEE	DEG_SCF_FBW7_2	0.0556
p.V256I	SIDM01753	Gastric Carcinoma	GDSC	LRVTPTEE	DEG_SCF_FBW7_2	0.0556
p.P230H	TCGA-EE-A3AE	SKCM	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.0833
p.R240W	TCGA-EO-A3B0	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.7523
p.P243H	TCGA-EY-A5W2	UCEC	TCGA	LRVTPTEE	DEG_SCF_FBW7_2	0.7694
p.R240Q	ACH-001651	Endometrial/Uterine Cancer	CCLE	LRVTPTEE	DEG_SCF_FBW7_2	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15599	Na	DEG_SCF_FBW7_2	239:246	LRVTPTEE	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons