DegronMD

Uniprot ID: O14745

Source protein: Na

Source gene: SLC9A3R1

Class: DEG_APCC_DBOX_1

Location: 150:158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 48.9111

COIL: 0.289

CONS_SCORE: 0.7476

DSS_SCORE: 0.6654

HELIX: 0.0299

FCONS_SCORE: 1.284

RIG_SCORE: 0.7174

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R151W	SIDM01248	Thyroid Gland Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.8634
p.R151W	SIDM01167	Thyroid Gland Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.8634
p.R151W	CGTH-W-1	thyroid	COSMIC	LRPRLCTMK	DEG_APCC_DBOX_1	0.8634
p.R151L	DO229038	LICA	ICGC	LRPRLCTMK	DEG_APCC_DBOX_1	0.8428
p.T158A	LS-411N	large_intestine	COSMIC	LRPRLCTMK	DEG_APCC_DBOX_1	0.7139
p.R153Q	SIDM00422	Hodgkin's Lymphoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM00908	Non-Cancerous	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM00852	Glioma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM00542	Glioblastoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM00909	Melanoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM00519	Mesothelioma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM01560	Rhabdomyosarcoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.R153Q	SIDM01709	Melanoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.6218
p.L150F	SIDM02034	Colorectal Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.587
p.P152S	TCGA-AX-A0J1	UCEC	TCGA	LRPRLCTMK	DEG_APCC_DBOX_1	0.5641
p.P152S	DO41199	UCEC	ICGC	LRPRLCTMK	DEG_APCC_DBOX_1	0.5641
p.R148H	SIDM01472	Hepatocellular Carcinoma	GDSC	LRPRLCTMK	DEG_APCC_DBOX_1	0.2778
p.H144Y	ACH-001970	Metastasis	CCLE	LRPRLCTMK	DEG_APCC_DBOX_1	0.1667

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14745	Na	DEG_APCC_DBOX_1	150:158	LRPRLCTMK	APC,CDC20,FZR1	0.9886	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons