DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_APCC_KENBOX_2

Location: 726:730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6976

ASA_SCORE: 110.26

COIL: 0.5354

CONS_SCORE: 0.2579

DSS_SCORE: 0.5944

HELIX: 0.4472

FCONS_SCORE: 0.9716

RIG_SCORE: 0.6885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G722E	TCGA-AR-A0TX	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	0.2222
p.G722E	DO1663	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.2222
p.R719M	TCGA-EW-A1PA	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	0.1389
p.R719M	DO5576	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.1389
p.E740K	TCGA-IR-A3LK	CESC	TCGA	QKENS	DEG_APCC_KENBOX_2	0.0556
p.E740K	TCGA-WS-AB45	COAD	TCGA	QKENS	DEG_APCC_KENBOX_2	0.0556
p.E740K	DO44299	CESC	ICGC	QKENS	DEG_APCC_KENBOX_2	0.0556
p.E740K	DO51734	COAD	ICGC	QKENS	DEG_APCC_KENBOX_2	0.0556
p.S730Y	DO229348	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6009
p.S730Y	DO227504	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6009
p.S730Y	DO227496	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6009
p.S730Y	DO221548	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6009
p.S730Y	DO231171	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6009
p.N729D	DO50844	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6932
p.N729D	DO45191	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	0.6932
p.E725K	SIDM00781	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.3056
p.E725K	SIDM00780	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.3056
p.E725K	ACH-000967	Colon/Colorectal Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	0.3056
p.E725K	ACH-001199	Colon/Colorectal Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	0.3056
p.E725K	SNU-C2B	large_intestine	COSMIC	QKENS	DEG_APCC_KENBOX_2	0.3056
p.S730F	SIDM00127	Oral Cavity Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.6871
p.S730F	JHU-022	upper_aerodigestive_tract	COSMIC	QKENS	DEG_APCC_KENBOX_2	0.6871
p.M737V	SIDM01638	Non-Cancerous	GDSC	QKENS	DEG_APCC_KENBOX_2	0.1389
p.M737V	SIDM00172	Head and Neck Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.1389
p.L732H	SIDM01473	Plasma Cell Myeloma	GDSC	QKENS	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14745	Na	DEG_APCC_KENBOX_2	265:269	QKENS	APC,CDC20,FZR1	0.9808	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_APCC_KENBOX_2	726:730	QKENS	APC,CDC20,FZR1	0.6976	More...
Q96GD4	Aurora kinase B	DEG_APCC_KENBOX_2	3:7	QKENS	APC,CDC20,FZR1	0.9973	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_APCC_KENBOX_2	174:178	QKENS	APC,CDC20,FZR1	0.6857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENS

Degron related mutations and impact score

Drug responses associated with KMT2C mutations

All proteins holding degron of QKENS