DegronMD

Uniprot ID: Q96GD4

Source protein: Aurora kinase B

Source gene: AURKB

Class: DEG_APCC_KENBOX_2

Location: 3:7

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 122.02

COIL: 0.9558

CONS_SCORE: 0.2574

DSS_SCORE: 0.7809

HELIX: 0.0292

FCONS_SCORE: 0.9963

RIG_SCORE: 0.6885

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2S	TCGA-DA-A1IB	SKCM	TCGA	QKENS	DEG_APCC_KENBOX_2	0.75
p.A2S	DO38033	SKCM	ICGC	QKENS	DEG_APCC_KENBOX_2	0.75
p.Y8C	DO233854	GACA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.75
p.T16K	DO228948	LICA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.5278
p.P9H	DO229024	LICA	ICGC	QKENS	DEG_APCC_KENBOX_2	0.2778
p.A17V	DO36556	READ	ICGC	QKENS	DEG_APCC_KENBOX_2	0.0556
p.R3H	SW48	large_intestine	COSMIC	QKENS	DEG_APCC_KENBOX_2	0.8244

Drug responses associated with AURKB mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A276T (No)	GDSC	Tozasertib	0.5486
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A276T (No)	GDSC	Genentech Cpd 10	0.4784
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A276T (No)	GDSC	BX795	7.4153
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A276T (No)	GDSC	SL0101	39.8103
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A276T (No)	GDSC	ZM447439	1.6423
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D255N (No)	GDSC	Tozasertib	0.5486
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D255N (No)	GDSC	Genentech Cpd 10	0.4784
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D255N (No)	GDSC	BX795	7.4153
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D255N (No)	GDSC	SL0101	39.8103
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D255N (No)	GDSC	ZM447439	1.6423
SIDM00689	DLBC\|B_cell_lymphoma	p.P325S (No)	GDSC	Tozasertib	0.6452
SIDM00689	DLBC\|B_cell_lymphoma	p.P325S (No)	GDSC	Genentech Cpd 10	0.7663
SIDM00689	DLBC\|B_cell_lymphoma	p.P325S (No)	GDSC	BX795	2.3406
SIDM00689	DLBC\|B_cell_lymphoma	p.P325S (No)	GDSC	SL0101	66.8944
SIDM00689	DLBC\|B_cell_lymphoma	p.P325S (No)	GDSC	ZM447439	3.2986
SIDM01066	SKCM\|melanoma	p.F88L (No)	GDSC	Genentech Cpd 10	6.4708
SIDM01066	SKCM\|melanoma	p.F88L (No)	GDSC	BX795	3.6414
SIDM01066	SKCM\|melanoma	p.F88L (No)	GDSC	SL0101	78.1452
SIDM01066	SKCM\|melanoma	p.F88L (No)	GDSC	ZM447439	14.9591
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.P325S (No)	GDSC	Genentech Cpd 10	110.7556
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.P325S (No)	GDSC	BX795	3.5303
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.P325S (No)	GDSC	SL0101	69.7657
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.P325S (No)	GDSC	ZM447439	5.2697
SIDM00217	COREAD\|large_intestine	p.R27* (No)	GDSC	Genentech Cpd 10	4.3168
SIDM00282	COREAD\|large_intestine	p.K202E (No)	GDSC	Tozasertib	58.7424
SIDM00282	COREAD\|large_intestine	p.K202E (No)	GDSC	Genentech Cpd 10	43.8314
SIDM00282	COREAD\|large_intestine	p.K202E (No)	GDSC	BX795	61.0584
SIDM00282	COREAD\|large_intestine	p.K202E (No)	GDSC	SL0101	154.8164
SIDM00282	COREAD\|large_intestine	p.K202E (No)	GDSC	ZM447439	32.7666
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	Genentech Cpd 10	2.1298
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	BX795	16.5393
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	SL0101	144.1903
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	ZM447439	31.0459
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	ZM447439	20.769
SIDM00928	BRCA\|breast	p.A52V (No)	GDSC	Tozasertib	162.76
SIDM01000	SKCM\|melanoma	p.*345R (No)	GDSC	Genentech Cpd 10	13.2193
SIDM01000	SKCM\|melanoma	p.*345R (No)	GDSC	BX795	3.9745
SIDM01000	SKCM\|melanoma	p.*345R (No)	GDSC	SL0101	82.0947
SIDM01000	SKCM\|melanoma	p.*345R (No)	GDSC	ZM447439	24.0847
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K194N (No)	GDSC	Genentech Cpd 10	102.3922
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K194N (No)	GDSC	BX795	10.2938
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K194N (No)	GDSC	SL0101	168.5696
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K194N (No)	GDSC	ZM447439	29.4113
SIDM00837	COREAD\|large_intestine	p.R284H (No)	GDSC	Genentech Cpd 10	2.0372
SIDM00837	COREAD\|large_intestine	p.R284H (No)	GDSC	BX795	2.1232
SIDM00837	COREAD\|large_intestine	p.R284H (No)	GDSC	SL0101	30.1232
SIDM00837	COREAD\|large_intestine	p.R284H (No)	GDSC	ZM447439	1.2652
SIDM00837	COREAD\|large_intestine	p.R44H (No)	GDSC	Genentech Cpd 10	2.0372
SIDM00837	COREAD\|large_intestine	p.R44H (No)	GDSC	BX795	2.1232
SIDM00837	COREAD\|large_intestine	p.R44H (No)	GDSC	SL0101	30.1232
SIDM00837	COREAD\|large_intestine	p.R44H (No)	GDSC	ZM447439	1.2652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14745	Na	DEG_APCC_KENBOX_2	265:269	QKENS	APC,CDC20,FZR1	0.9808	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_APCC_KENBOX_2	726:730	QKENS	APC,CDC20,FZR1	0.6976	More...
Q96GD4	Aurora kinase B	DEG_APCC_KENBOX_2	3:7	QKENS	APC,CDC20,FZR1	0.9973	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_APCC_KENBOX_2	174:178	QKENS	APC,CDC20,FZR1	0.6857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENS

Degron related mutations and impact score

Drug responses associated with AURKB mutations

All proteins holding degron of QKENS