DegronMD

Uniprot ID: Q9BSD3

Source protein: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Source gene: RHNO1

Class: DEG_SCF_FBW7_1

Location: 157:163

E3 ligase: FBXW7

DEGRON score: 0.9721

ASA_SCORE: 75.3714

COIL: 0.8839

CONS_SCORE: 0.6608

DSS_SCORE: 0.5039

HELIX: 0.049

FCONS_SCORE: 1.4582

RIG_SCORE: 0.6898

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162A	DO225348	BRCA	ICGC	IQTPESS	DEG_SCF_FBW7_1	0.6477
p.E154K	EN	endometrium	COSMIC	IQTPESS	DEG_SCF_FBW7_1	0.25
p.E168K	TCGA-AP-A1DV	UCEC	TCGA	IQTPESS	DEG_SCF_FBW7_1	0.1944
p.E168K	DO43186	UCEC	ICGC	IQTPESS	DEG_SCF_FBW7_1	0.1944
p.E168K	SIDM01045	Endometrial Carcinoma	GDSC	IQTPESS	DEG_SCF_FBW7_1	0.1944
p.E168K	ACH-000978	Endometrial/Uterine Cancer	CCLE	IQTPESS	DEG_SCF_FBW7_1	0.1944
p.E168K	EN	endometrium	COSMIC	IQTPESS	DEG_SCF_FBW7_1	0.1944
p.P171L	TCGA-DU-6407	LGG	TCGA	IQTPESS	DEG_SCF_FBW7_1	0.1111
p.P171L	TCGA-EE-A29D	SKCM	TCGA	IQTPESS	DEG_SCF_FBW7_1	0.1111
p.P171L	DO22295	LGG	ICGC	IQTPESS	DEG_SCF_FBW7_1	0.1111
p.P171L	DO38123	SKCM	ICGC	IQTPESS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SCF_FBW7_1	157:163	IQTPESS	FBXW7	0.9721	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons