DegronMD

Uniprot ID: Q9BSD3

Source protein: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Source gene: RHNO1

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8615

ASA_SCORE: 88.7111

COIL: 0.8464

CONS_SCORE: 0.5224

DSS_SCORE: 0.4496

HELIX: 0.0347

FCONS_SCORE: 1.1494

RIG_SCORE: 0.7394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P127S	TCGA-19-1787	GBM	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	0.5641
p.P127S	DO13522	GBM	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	0.5641
p.G138V	TCGA-43-5668	LUSC	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	0.1667
p.G138V	DO26608	LUSC	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	0.1667
p.P134S	TCGA-A5-A0G2	UCEC	TCGA	SRRPLVPVL	DEG_APCC_DBOX_1	0.2778
p.P134S	DO41235	UCEC	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	0.2778
p.C115F	DO229009	LICA	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	0.0833
p.S119L	DO220877	MELA	ICGC	SRRPLVPVL	DEG_APCC_DBOX_1	0.1944
p.S136R	SIDM00340	Plasma Cell Myeloma	GDSC	SRRPLVPVL	DEG_APCC_DBOX_1	0.2222
p.S136R	ACH-000204	Myeloma	CCLE	SRRPLVPVL	DEG_APCC_DBOX_1	0.2222
p.S136R	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLVPVL	DEG_APCC_DBOX_1	0.2222
p.L132R	SIDM00632	Non-Cancerous	GDSC	SRRPLVPVL	DEG_APCC_DBOX_1	0.7316
p.S122R	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLVPVL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_APCC_DBOX_1	124:132	SRRPLVPVL	APC,CDC20,FZR1	0.8615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons