DegronMD

Uniprot ID: P15884

Source protein: Transcription factor 4

Source gene: TCF4

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.9306

ASA_SCORE: 49.66

COIL: 0.8704

CONS_SCORE: 0.3585

DSS_SCORE: 0.5052

HELIX: 0.0746

FCONS_SCORE: 0.879

RIG_SCORE: 0.6204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R259Q	TCGA-FS-A1ZZ	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	0.1667
p.G239R	TCGA-NK-A5CT	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.0556
p.H247Q	DO224662	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.S245C	DO2155	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.2222
p.L242F	DO24830	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1389
p.P259L	DO220902	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.E261K	DO47281	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1111
p.S252N	DO41199	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.7069
p.S252N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.7069
p.S242T	SIDM00541	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1389
p.S242T	HT55	large_intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1389
p.P243R	SIDM00301	Pancreatic Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.P243R	KP-4	pancreas	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1667
p.S241L	ACH-002338	Skin Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	0.1111
p.S241L	ACH-002510	Skin Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	0.1111
p.P255A	NCI-H1869	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.P254A	NCI-H1869	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.3056
p.S251T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.6005
p.S250N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.7069
p.S249T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.7116
p.G242V	NCI-SNU-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1389
p.P254L	SNU-1040	large_intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.3056
p.T255K	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.P255L	SNU-1040	large_intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.G260V	NCI-SNU-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1389
p.S258N	SNG-M	endometrium	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.1944
p.S257T	IST-MEL1	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	1117:1121	PQSSS	SPOP	0.9855	More...
O60271	C-Jun-amino-terminal kinase-interacting protein 4	DEG_SPOP_SBC_1	1239:1243	PQSSS	SPOP	0.9213	More...
O95409	Zinc finger protein ZIC 2	DEG_SPOP_SBC_1	447:451	PQSSS	SPOP	0.931	More...
O95835	Serine/threonine-protein kinase LATS1	DEG_SPOP_SBC_1	434:438	PQSSS	SPOP	0.9911	More...
O96013	Serine/threonine-protein kinase PAK 4	DEG_SPOP_SBC_1	240:244	PQSSS	SPOP	0.6645	More...
P0CB47	Upstream-binding factor 1-like protein 1	DEG_SPOP_SBC_1	325:329	PQSSS	SPOP	0.8335	More...
P15884	Transcription factor 4	DEG_SPOP_SBC_1	249:253	PQSSS	SPOP	0.9306	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	60:64	PQSSS	SPOP	0.674	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	1582:1586	PQSSS	SPOP	0.989	More...
P49023	Paxillin	DEG_SPOP_SBC_1	81:85	PQSSS	SPOP	0.9894	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	138:142	PQSSS	SPOP	0.9993	More...
Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	DEG_SPOP_SBC_1	887:891	PQSSS	SPOP	0.997	More...
Q2TAZ0	Autophagy-related protein 2 homolog A	DEG_SPOP_SBC_1	742:746	PQSSS	SPOP	0.9683	More...
Q5TCM9	Late cornified envelope protein 5A	DEG_SPOP_SBC_1	82:86	PQSSS	SPOP	0.798	More...
Q6UY09	Carcinoembryonic antigen-related cell adhesion molecule 20	DEG_SPOP_SBC_1	438:442	PQSSS	SPOP	0.8914	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	299:303	PQSSS	SPOP	0.8349	More...
Q8NCP5	Zinc finger and BTB domain-containing protein 44	DEG_SPOP_SBC_1	334:338	PQSSS	SPOP	0.902	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	477:481	PQSSS	SPOP	0.9239	More...
Q8NHY3	GAS2-like protein 2	DEG_SPOP_SBC_1	384:388	PQSSS	SPOP	0.9783	More...
Q8TDM6	Disks large homolog 5	DEG_SPOP_SBC_1	797:801	PQSSS	SPOP	0.9776	More...
Q8WXI9	Transcriptional repressor p66-beta	DEG_SPOP_SBC_1	300:304	PQSSS	SPOP	0.9946	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	519:523	PQSSS	SPOP	0.9325	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	99:103	PQSSS	SPOP	0.9292	More...
Q9BWV1	Brother of CDO	DEG_SPOP_SBC_1	592:596	PQSSS	SPOP	0.7123	More...
Q9H5V7	Zinc finger protein Pegasus	DEG_SPOP_SBC_1	305:309	PQSSS	SPOP	0.6593	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	322:326	PQSSS	SPOP	0.9692	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	739:743	PQSSS	SPOP	0.9901	More...
Q9UNW9	RNA-binding protein Nova-2	DEG_SPOP_SBC_1	204:208	PQSSS	SPOP	0.9633	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	413:417	PQSSS	SPOP	0.9895	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	83:87	PQSSS	SPOP	0.8965	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	129:133	PQSSS	SPOP	0.9781	More...
F5H4B4	Protein FAM227A	DEG_SPOP_SBC_1	345:349	PQSSS	SPOP	0.9381	More...
P0CB48	Putative upstream-binding factor 1-like protein 6	DEG_SPOP_SBC_1	332:336	PQSSS	SPOP	0.5892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSSS

Degron related mutations and impact score

Drug responses associated with TCF4 mutations

All proteins holding degron of PQSSS