DegronMD - Q15147(PLCB4)

FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. {ECO:0000250|UniProtKB:Q07722}.

GO - Biological processes (BP): G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]

GO - Molecular function (MF): calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]

GO - Cellular component (CC): cytosol [GO:0005829]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S889R	SIDM00933	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.S889R	ACH-000856	Breast Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.S889R	CAL-51	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.S890I	TCGA-BH-A0DE	BRCA	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	TCGA-BH-A0DE	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.S890I	DO2688	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	DO2688	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.S890I	DO222539	ESCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	DO222539	ESCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.P887H	TCGA-BF-A1PU	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7694
p.P887H	TCGA-BF-A1PU	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7694
p.P887H	DO50278	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7694
p.P887H	DO50278	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7694
p.S889R	SIDM00933	Breast Carcinoma	GDSC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.S889R	ACH-000856	Breast Cancer	CCLE	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.S889R	CAL-51	breast	COSMIC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.G888E	MZ2-MEL	skin	COSMIC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7199
p.G888E	MZ2-MEL	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7199
p.Q888H	TCGA-69-7979	LUAD	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.647
p.Q888H	TCGA-69-7979	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.647

Showing 1 to 20 of 74 entries

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No resistance data available for this Degron.

Kaplan plot for PLCB4 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCB4

UniProt ID: Q15147

Entrez ID: 5332

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for PLCB4 in