DegronMD - Q15147(PLCB4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A881T	TCGA-02-2470	GBM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881T	TCGA-02-2470	GBM	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.A881T	TCGA-EI-6881	READ	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881T	TCGA-EI-6881	READ	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.A881T	DO13516	GBM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881T	DO13516	GBM	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.A881T	DO37098	READ	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881T	DO37098	READ	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.P895S	TCGA-39-5019	LUSC	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1944
p.P895S	TCGA-39-5019	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.2222
p.P895S	DO26538	LUSC	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1944
p.P895S	DO26538	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.2222
p.Q888H	TCGA-69-7979	LUAD	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.647
p.Q888H	TCGA-69-7979	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.647
p.Q888H	DO23874	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.647
p.Q888H	DO23874	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.647
p.A878T	TCGA-86-A4JF	LUAD	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1389
p.A878T	TCGA-86-A4JF	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0833
p.A878T	TCGA-DX-AB2E	SARC	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1389
p.A878T	TCGA-DX-AB2E	SARC	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0833
p.A878T	DO45317	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1389
p.A878T	DO45317	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0833
p.A878T	DO220073	SARC	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1389
p.A878T	DO220073	SARC	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0833
p.P887H	TCGA-BF-A1PU	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7694
p.P887H	TCGA-BF-A1PU	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7694
p.P887H	DO50278	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7694
p.P887H	DO50278	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7694
p.S890I	TCGA-BH-A0DE	BRCA	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	TCGA-BH-A0DE	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.S890I	DO2688	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	DO2688	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.S890I	DO222539	ESCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.8453
p.S890I	DO222539	ESCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8453
p.S891T	TCGA-CN-4739	HNSC	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.6005
p.S891T	DO14478	HNSC	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.6005
p.T898M	TCGA-E9-A248	BRCA	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1111
p.T898M	TCGA-E9-A248	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1389
p.T898M	DO1191	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1111
p.T898M	DO1191	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1389
p.T898M	DO3328	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1111
p.T898M	DO3328	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1389
p.G876E	TCGA-EE-A17X	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	TCGA-EE-A20F	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	TCGA-EE-A2MN	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	TCGA-FS-A1ZS	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO220851	MELA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO222438	MELA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO229494	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO218850	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO37806	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO37423	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO37961	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	DO37931	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	ACH-002165	Skin Cancer	CCLE	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.G876E	MZ2-MEL	skin	COSMIC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.A881S	DO229036	LICA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881S	DO229036	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.A881S	DO25189	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.2222
p.A881S	DO25189	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.1667
p.G876R	DO229467	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.0833
p.S889R	SIDM00933	Breast Carcinoma	GDSC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.S889R	SIDM00933	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.S889R	ACH-000856	Breast Cancer	CCLE	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.S889R	ACH-000856	Breast Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.S889R	CAL-51	breast	COSMIC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7427
p.S889R	CAL-51	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.8538
p.P895Q	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1944
p.P895Q	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.2222
p.P895Q	ACH-000604	Leukemia	CCLE	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation rewiring degron network	0.1944
p.P895Q	ACH-000604	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.2222
p.S901R	CAL-51	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation rewiring degron network	0.0556
p.G888E	MZ2-MEL	skin	COSMIC	VTPQSS	DEG_SCF_FBW7_1	885:890	Mutation altering degron motif	0.7199
p.G888E	MZ2-MEL	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	887:891	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCB4

UniProt ID: Q15147

Entrez ID: 5332

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCB4 in