DegronMD

Uniprot ID: Q15147

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

Source gene: PLCB4

Class: DEG_SCF_FBW7_1

Location: 885:890

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 87.65

COIL: 0.9203

CONS_SCORE: 0.24

DSS_SCORE: 0.6325

HELIX: 0.0585

FCONS_SCORE: 0.991

RIG_SCORE: 0.6611

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A881T	TCGA-02-2470	GBM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.A881T	TCGA-EI-6881	READ	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.A881T	DO13516	GBM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.A881T	DO37098	READ	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.P895S	TCGA-39-5019	LUSC	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.1944
p.P895S	DO26538	LUSC	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.1944
p.Q888H	TCGA-69-7979	LUAD	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.647
p.Q888H	DO23874	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.647
p.A878T	TCGA-86-A4JF	LUAD	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.1389
p.A878T	TCGA-DX-AB2E	SARC	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.1389
p.A878T	DO45317	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.1389
p.A878T	DO220073	SARC	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.1389
p.P887H	TCGA-BF-A1PU	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.7694
p.P887H	DO50278	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.7694
p.S890I	TCGA-BH-A0DE	BRCA	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.8453
p.S890I	DO2688	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.8453
p.S890I	DO222539	ESCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.8453
p.T898M	TCGA-E9-A248	BRCA	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.1111
p.T898M	DO1191	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.1111
p.T898M	DO3328	BRCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.1111
p.G876E	TCGA-EE-A17X	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	TCGA-EE-A20F	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	TCGA-EE-A2MN	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	TCGA-FS-A1ZS	SKCM	TCGA	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO220851	MELA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO222438	MELA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO229494	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO218850	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO37806	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO37423	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO37961	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	DO37931	SKCM	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	ACH-002165	Skin Cancer	CCLE	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.G876E	MZ2-MEL	skin	COSMIC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.A881S	DO229036	LICA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.A881S	DO25189	LUAD	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.2222
p.G876R	DO229467	SKCA	ICGC	VTPQSS	DEG_SCF_FBW7_1	0.0833
p.S889R	SIDM00933	Breast Carcinoma	GDSC	VTPQSS	DEG_SCF_FBW7_1	0.7427
p.S889R	ACH-000856	Breast Cancer	CCLE	VTPQSS	DEG_SCF_FBW7_1	0.7427
p.S889R	CAL-51	breast	COSMIC	VTPQSS	DEG_SCF_FBW7_1	0.7427
p.P895Q	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VTPQSS	DEG_SCF_FBW7_1	0.1944
p.P895Q	ACH-000604	Leukemia	CCLE	VTPQSS	DEG_SCF_FBW7_1	0.1944
p.G888E	MZ2-MEL	skin	COSMIC	VTPQSS	DEG_SCF_FBW7_1	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPQSS

Degron related mutations and impact score

Drug responses associated with PLCB4 mutations

All proteins holding degron of VTPQSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	DEG_SCF_FBW7_1	885:890	VTPQSS	FBXW7	0.9952	More...