DegronMD - Q9UQ35(SRRM2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1501L	TCGA-05-4397	LUAD	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.5278
p.S1501L	DO25320	LUAD	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.5278
p.Q1290L	TCGA-12-0829	GBM	TCGA	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.2778
p.Q1290L	DO11166	GBM	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.2778
p.C1509Y	TCGA-22-5473	LUSC	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.3056
p.C1509Y	DO26467	LUSC	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.3056
p.T1208S	TCGA-2Y-A9GY	LIHC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.8227
p.T1208S	DO219515	LIHC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.8227
p.Q1400K	TCGA-39-5040	LUSC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.0556
p.Q1400K	DO45436	LUSC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.0556
p.T1511I	TCGA-4A-A93Y	KIRP	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation altering degron motif	0.8189
p.T1511I	DO219690	KIRP	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation altering degron motif	0.8189
p.L1282F	TCGA-61-2087	OV	TCGA	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.0556
p.L1282F	DO32039	OV	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.0556
p.L1200M	TCGA-91-6835	LUAD	TCGA	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation rewiring degron network	0.1667
p.L1200M	DO26082	LUAD	ICGC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation rewiring degron network	0.1667
p.A308V	TCGA-A5-A1OF	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1944
p.A308V	DO42568	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1944
p.R303H	TCGA-A6-2686	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556
p.R303H	DO7828	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556
p.R303H	DO228546	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556
p.S2607C	TCGA-AC-A23H	BRCA	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation blocking phosphorylation signal	0.6389
p.S2607C	DO2401	BRCA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation blocking phosphorylation signal	0.6389
p.K2587N	TCGA-AX-A2HC	UCEC	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation substituting flanking lysine	0.2222
p.K2587N	DO41572	UCEC	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation substituting flanking lysine	0.2222
p.E1047K	TCGA-B5-A3FA	UCEC	TCGA	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	TCGA-FD-A3NA	BLCA	TCGA	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	DO602	BLCA	ICGC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	DO52402	UCEC	ICGC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	SIDM01039	Other Solid Cancers	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	SIDM00796	Head and Neck Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	SIDM00213	Thyroid Gland Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.E1047K	SIDM00228	Thyroid Gland Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.2222
p.S1403Y	TCGA-BS-A0UV	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.5833
p.S1403Y	DO42793	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.5833
p.E1515Q	TCGA-BT-A3PH	BLCA	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation altering degron motif	0.6744
p.E1515Q	DO856	BLCA	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation altering degron motif	0.6744
p.G304R	TCGA-CG-5723	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.G304R	DO38376	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.E1212Q	TCGA-CN-4723	HNSC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.6744
p.E1212Q	DO14830	HNSC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.6744
p.P2586Q	TCGA-D3-A1QA	SKCM	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.0833
p.P2586Q	DO47469	SKCM	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.0833
p.K2604T	TCGA-D9-A6EC	SKCM	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2778
p.K2604T	DO50291	SKCM	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2778
p.R1207S	TCGA-DD-AAEK	LIHC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.6316
p.R1207S	DO52273	LIHC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation altering degron motif	0.6316
p.S1501A	TCGA-DF-A2KU	UCEC	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.5278
p.S1501A	DO223286	UCEC	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.5278
p.S1424P	TCGA-DI-A1BU	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.5833
p.S1424P	DO42023	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.5833
p.D1408H	TCGA-DK-A2I4	BLCA	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.2778
p.D1408H	DO465	BLCA	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.2778
p.Q1290H	TCGA-DU-6392	LGG	TCGA	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.2778
p.Q1290H	DO22237	LGG	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.2778
p.A1291V	TCGA-DU-6392	LGG	TCGA	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.3056
p.A1291V	DO22237	LGG	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.3056
p.S1517I	TCGA-DX-A6YV	SARC	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.7222
p.S1517I	DO220011	SARC	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation blocking phosphorylation signal	0.7222
p.R320Q	TCGA-EO-A22U	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.R320Q	DO43755	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.R1412I	TCGA-EY-A215	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation altering degron motif	0.6991
p.R1412I	DO42665	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation altering degron motif	0.6991
p.R2603Q	TCGA-EY-A2OP	UCEC	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.3056
p.R2603Q	DO51530	PACA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.3056
p.R2603Q	DO42560	UCEC	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.3056
p.S1032F	TCGA-GF-A3OT	SKCM	TCGA	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation blocking phosphorylation signal	0.5833
p.S1032F	DO47288	SKCM	ICGC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation blocking phosphorylation signal	0.5833
p.P324Q	TCGA-GN-A26D	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.P324Q	DO37480	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.S1041Y	TCGA-KL-8337	KICH	TCGA	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation altering degron motif	0.8231
p.S1041Y	DO220345	KICH	ICGC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation altering degron motif	0.8231
p.A1409V	TCGA-MH-A854	KIRP	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.3056
p.A1409V	DO49773	KIRP	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.3056
p.M1427I	TCGA-P3-A5QF	HNSC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.0556
p.M1427I	DO44439	HNSC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation rewiring degron network	0.0556
p.L1505P	TCGA-UZ-A9PO	KIRP	TCGA	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.1944
p.L1505P	DO219704	KIRP	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.1944
p.P897L	DO48385	BLCA	ICGC	VKSST	DEG_SPOP_SBC_1	899:903	Mutation rewiring degron network	0.2778
p.S1199L	DO225266	BRCA	ICGC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation blocking phosphorylation signal	0.5833
p.D1285N	DO225366	BRCA	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.1389
p.R11W	DO227994	COCA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7523
p.P309T	DO233089	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2222
p.V19I	DO233737	GACA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1667
p.G1518R	DO233888	GACA	ICGC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.25
p.L1293V	DO233830	GACA	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation altering degron motif	0.5654
p.S908N	DO228585	LICA	ICGC	VKSST	DEG_SPOP_SBC_1	899:903	Mutation blocking phosphorylation signal	0.6389
p.R2606C	DO228556	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2222
p.R2606C	DO51537	PACA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2222
p.A2589S	DO229027	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.1667
p.R303L	DO229035	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556
p.R2594C	DO229035	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.3056
p.P2586A	DO23541	LIRI	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.0833
p.R11L	DO230530	LUSC	ICGC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7316
p.S1304F	DO228322	MALY	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.25
p.E305D	DO232048	ORCA	ICGC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.G1306S	DO232761	PBCA	ICGC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation rewiring degron network	0.1944
p.A2585S	DO229259	THCA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.0556
p.P8Q	DO229240	THCA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.5924
p.R403P	SIDM00557	Neuroblastoma	GDSC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403P	ACH-000345	Neuroblastoma	CCLE	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403P	KP-N-RT-BM-1	autonomic ganglia	COSMIC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.L1033V	SIDM00064	Hepatocellular Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM00002	Neuroblastoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM01653	Non-Cancerous	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM00207	Glioblastoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM01682	Gastric Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM01412	Oral Cavity Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM01511	Gastric Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.L1033V	SIDM01660	Kidney Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1667
p.C1036S	SIDM00777	Colorectal Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.C1036S	SIDM01161	Other Sarcomas	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.C1036S	SIDM00899	Pancreatic Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.C1036S	SIDM00130	Pancreatic Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.C1036S	SIDM00309	Mesothelioma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.C1036S	SIDM01592	Breast Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.25
p.R403H	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403H	ACH-000444	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403H	LU-99A	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403C	SIDM00087	Plasma Cell Myeloma	GDSC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403C	ACH-000817	Myeloma	CCLE	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R403C	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.R21H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1111
p.R21H	ACH-002256	Leukemia	CCLE	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1111
p.R21H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1111
p.N1506I	SIDM00860	Head and Neck Carcinoma	GDSC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.2222
p.R2606H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2222
p.R2606H	ACH-000953	Leukemia	CCLE	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2222
p.R2606H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.2222
p.G1217V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation rewiring degron network	0.1944
p.G1217V	ACH-001364	Lung Cancer	CCLE	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation rewiring degron network	0.1944
p.G1217V	NCI-H345	lung	COSMIC	LRTPPRE	DEG_SCF_FBW7_2	1206:1212	Mutation rewiring degron network	0.1944
p.S311G	SIDM00032	Bladder Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation blocking phosphorylation signal	0.7222
p.S311G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation blocking phosphorylation signal	0.7222
p.S311G	SIDM00785	Acute Myeloid Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation blocking phosphorylation signal	0.7222
p.S311G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation blocking phosphorylation signal	0.7222
p.S311G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation blocking phosphorylation signal	0.7222
p.S1292A	SIDM00929	Chondrosarcoma	GDSC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation altering degron motif	0.7588
p.S1292A	SIDM00721	Small Cell Lung Carcinoma	GDSC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation altering degron motif	0.7588
p.S421I	SIDM00677	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.6667
p.S421I	ACH-000007	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.6667
p.S421I	LS-513	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.6667
p.S1419R	SIDM00485	Oral Cavity Carcinoma	GDSC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.7222
p.S1419R	ACH-000794	Head and Neck Cancer	CCLE	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.7222
p.S1419R	BICR22	upper aerodigestive tract	COSMIC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation blocking phosphorylation signal	0.7222
p.S1415L	SIDM01617	Endometrial Carcinoma	GDSC	VPRTPSRE	DEG_SCF_FBW7_2	1410:1417	Mutation altering degron motif	0.7667
p.P2596L	SIDM01749	Osteosarcoma	GDSC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.6471
p.S1311F	SIDM01753	Gastric Carcinoma	GDSC	SLEAVEVPSM	DEG_COP1_1	1292:1301	Mutation blocking phosphorylation signal	0.5
p.G14D	ACH-000961	Endometrial/Uterine Cancer	CCLE	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.3056
p.S1034F	ACH-001100		CCLE	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation blocking phosphorylation signal	0.6389
p.G1051A	ACH-001134	Lymphoma	CCLE	VKSST	DEG_SPOP_SBC_1	1039:1043	Mutation rewiring degron network	0.1111
p.A21V	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1111
p.N1506H	FADU	upper aerodigestive tract	COSMIC	LTPQRE	DEG_SCF_FBW7_2	1510:1515	Mutation rewiring degron network	0.2222
p.Q18H	NCI-H187	lung	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	7:13	Mutation blocking phosphorylation signal	0.6389
p.A327V	NCI-H630	large intestine	COSMIC	PGTTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRRM2

UniProt ID: Q9UQ35

Entrez ID: 23524

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SRRM2 in