DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SCF_SKP2-CKS1_1

Location: 2595:2602

E3 ligase: SKP2,CSK1

DEGRON score: 0.9982

ASA_SCORE: 110.3

COIL: 0.9685

CONS_SCORE: 0.3719

DSS_SCORE: 0.7851

HELIX: 0.0181

FCONS_SCORE: 1.0643

RIG_SCORE: 0.5731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2607C	TCGA-AC-A23H	BRCA	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S2607C	DO2401	BRCA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.6389
p.K2587N	TCGA-AX-A2HC	UCEC	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.K2587N	DO41572	UCEC	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2586Q	TCGA-D3-A1QA	SKCM	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P2586Q	DO47469	SKCM	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K2604T	TCGA-D9-A6EC	SKCM	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K2604T	DO50291	SKCM	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R2603Q	TCGA-EY-A2OP	UCEC	TCGA	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R2603Q	DO51530	PACA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R2603Q	DO42560	UCEC	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.R2606C	DO228556	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R2606C	DO51537	PACA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A2589S	DO229027	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R2594C	DO229035	LICA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P2586A	DO23541	LIRI	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A2585S	DO229259	THCA	ICGC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R2606H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R2606H	ACH-000953	Leukemia	CCLE	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R2606H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2596L	SIDM01749	Osteosarcoma	GDSC	PPEPTPAK	DEG_SCF_SKP2-CKS1_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SCF_SKP2-CKS1_1	2595:2602	PPEPTPAK	SKP2,CSK1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons