DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SPOP_SBC_1

Location: 1039:1043

E3 ligase: SPOP

DEGRON score: 0.994

ASA_SCORE: 101.3

COIL: 0.9628

CONS_SCORE: 0.3522

DSS_SCORE: 0.3723

HELIX: 0.009

FCONS_SCORE: 1.0428

RIG_SCORE: 0.6302

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1047K	TCGA-B5-A3FA	UCEC	TCGA	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	TCGA-FD-A3NA	BLCA	TCGA	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	DO602	BLCA	ICGC	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	DO52402	UCEC	ICGC	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	SIDM01039	Other Solid Cancers	GDSC	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	SIDM00796	Head and Neck Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	SIDM00213	Thyroid Gland Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.2222
p.E1047K	SIDM00228	Thyroid Gland Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.2222
p.S1032F	TCGA-GF-A3OT	SKCM	TCGA	VKSST	DEG_SPOP_SBC_1	0.5833
p.S1032F	DO47288	SKCM	ICGC	VKSST	DEG_SPOP_SBC_1	0.5833
p.S1041Y	TCGA-KL-8337	KICH	TCGA	VKSST	DEG_SPOP_SBC_1	0.8231
p.S1041Y	DO220345	KICH	ICGC	VKSST	DEG_SPOP_SBC_1	0.8231
p.L1033V	SIDM00064	Hepatocellular Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM00002	Neuroblastoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM01653	Non-Cancerous	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM00207	Glioblastoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM01682	Gastric Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM01412	Oral Cavity Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM01511	Gastric Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.L1033V	SIDM01660	Kidney Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.1667
p.C1036S	SIDM00777	Colorectal Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.C1036S	SIDM01161	Other Sarcomas	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.C1036S	SIDM00899	Pancreatic Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.C1036S	SIDM00130	Pancreatic Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.C1036S	SIDM00309	Mesothelioma	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.C1036S	SIDM01592	Breast Carcinoma	GDSC	VKSST	DEG_SPOP_SBC_1	0.25
p.S1034F	ACH-001100		CCLE	VKSST	DEG_SPOP_SBC_1	0.6389
p.G1051A	ACH-001134	Lymphoma	CCLE	VKSST	DEG_SPOP_SBC_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKSST

Degron related mutations and impact score

Drug responses associated with SRRM2 mutations

All proteins holding degron of VKSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	140:144	VKSST	SPOP	0.964	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	899:903	VKSST	SPOP	0.899	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	1039:1043	VKSST	SPOP	0.994	More...