DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKSST
Uniprot ID:
Q9UQ35
Source protein:
Serine/arginine repetitive matrix protein 2
Source gene:
SRRM2
Class:
DEG_SPOP_SBC_1
Location:
899:903
E3 ligase:
SPOP
DEGRON score:
0.899
ASA_SCORE:
108.4
COIL:
0.9608
CONS_SCORE:
0.4458
DSS_SCORE:
0.8152
HELIX:
0.0104
FCONS_SCORE:
0.9458
RIG_SCORE:
0.5013
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P897L
DO48385
BLCA
ICGC
VKSST
DEG_SPOP_SBC_1
0.2778
p.S908N
DO228585
LICA
ICGC
VKSST
DEG_SPOP_SBC_1
0.6389
Drug responses associated with SRRM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZUT1
Uncharacterized protein NKAPD1
DEG_SPOP_SBC_1
140:144
VKSST
SPOP
0.964
More...
Q9UQ35
Serine/arginine repetitive matrix protein 2
DEG_SPOP_SBC_1
899:903
VKSST
SPOP
0.899
More...
Q9UQ35
Serine/arginine repetitive matrix protein 2
DEG_SPOP_SBC_1
1039:1043
VKSST
SPOP
0.994
More...