DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKSST
Uniprot ID:
Q6ZUT1
Source protein:
Uncharacterized protein NKAPD1
Source gene:
NKAPD1
Class:
DEG_SPOP_SBC_1
Location:
140:144
E3 ligase:
SPOP
DEGRON score:
0.964
ASA_SCORE:
106.68
COIL:
0.9128
CONS_SCORE:
0.5172
DSS_SCORE:
0.8358
HELIX:
0.0524
FCONS_SCORE:
0.9673
RIG_SCORE:
0.5667
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D130G
SIDM00664
Pancreatic Carcinoma
GDSC
VKSST
DEG_SPOP_SBC_1
0.0556
p.D130G
Hs766T
pancreas
COSMIC
VKSST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with NKAPD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZUT1
Uncharacterized protein NKAPD1
DEG_SPOP_SBC_1
140:144
VKSST
SPOP
0.964
More...
Q9UQ35
Serine/arginine repetitive matrix protein 2
DEG_SPOP_SBC_1
899:903
VKSST
SPOP
0.899
More...
Q9UQ35
Serine/arginine repetitive matrix protein 2
DEG_SPOP_SBC_1
1039:1043
VKSST
SPOP
0.994
More...