DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SCF_FBW7_1

Location: 7:13

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 60.3143

COIL: 0.8403

CONS_SCORE: 0.9442

DSS_SCORE: 0.5652

HELIX: 0.0387

FCONS_SCORE: 1.0033

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11W	DO227994	COCA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	0.7523
p.V19I	DO233737	GACA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	0.1667
p.R11L	DO230530	LUSC	ICGC	LPTPRGS	DEG_SCF_FBW7_1	0.7316
p.P8Q	DO229240	THCA	ICGC	LPTPRGS	DEG_SCF_FBW7_1	0.5924
p.R21H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPTPRGS	DEG_SCF_FBW7_1	0.1111
p.R21H	ACH-002256	Leukemia	CCLE	LPTPRGS	DEG_SCF_FBW7_1	0.1111
p.R21H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	0.1111
p.G14D	ACH-000961	Endometrial/Uterine Cancer	CCLE	LPTPRGS	DEG_SCF_FBW7_1	0.3056
p.A21V	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	0.1111
p.Q18H	NCI-H187	lung	COSMIC	LPTPRGS	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SCF_FBW7_1	7:13	LPTPRGS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons