DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SCF_FBW7_2

Location: 1410:1417

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 119.575

COIL: 0.9661

CONS_SCORE: 0.4699

DSS_SCORE: 0.7064

HELIX: 0.0205

FCONS_SCORE: 1.1639

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1400K	TCGA-39-5040	LUSC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.0556
p.Q1400K	DO45436	LUSC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.0556
p.S1403Y	TCGA-BS-A0UV	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.5833
p.S1403Y	DO42793	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.5833
p.S1424P	TCGA-DI-A1BU	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.5833
p.S1424P	DO42023	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.5833
p.D1408H	TCGA-DK-A2I4	BLCA	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.2778
p.D1408H	DO465	BLCA	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.2778
p.R1412I	TCGA-EY-A215	UCEC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.6991
p.R1412I	DO42665	UCEC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.6991
p.A1409V	TCGA-MH-A854	KIRP	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.3056
p.A1409V	DO49773	KIRP	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.3056
p.M1427I	TCGA-P3-A5QF	HNSC	TCGA	VPRTPSRE	DEG_SCF_FBW7_2	0.0556
p.M1427I	DO44439	HNSC	ICGC	VPRTPSRE	DEG_SCF_FBW7_2	0.0556
p.S1419R	SIDM00485	Oral Cavity Carcinoma	GDSC	VPRTPSRE	DEG_SCF_FBW7_2	0.7222
p.S1419R	ACH-000794	Head and Neck Cancer	CCLE	VPRTPSRE	DEG_SCF_FBW7_2	0.7222
p.S1419R	BICR22	upper_aerodigestive_tract	COSMIC	VPRTPSRE	DEG_SCF_FBW7_2	0.7222
p.S1415L	SIDM01617	Endometrial Carcinoma	GDSC	VPRTPSRE	DEG_SCF_FBW7_2	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SCF_FBW7_2	1410:1417	VPRTPSRE	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons