DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_COP1_1

Location: 1292:1301

E3 ligase: COP1

DEGRON score: 0.929

ASA_SCORE: 99.53

COIL: 0.8154

CONS_SCORE: 0.331

DSS_SCORE: 0.5382

HELIX: 0.1405

FCONS_SCORE: 0.9445

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1290L	TCGA-12-0829	GBM	TCGA	SLEAVEVPSM	DEG_COP1_1	0.2778
p.Q1290L	DO11166	GBM	ICGC	SLEAVEVPSM	DEG_COP1_1	0.2778
p.L1282F	TCGA-61-2087	OV	TCGA	SLEAVEVPSM	DEG_COP1_1	0.0556
p.L1282F	DO32039	OV	ICGC	SLEAVEVPSM	DEG_COP1_1	0.0556
p.Q1290H	TCGA-DU-6392	LGG	TCGA	SLEAVEVPSM	DEG_COP1_1	0.2778
p.Q1290H	DO22237	LGG	ICGC	SLEAVEVPSM	DEG_COP1_1	0.2778
p.A1291V	TCGA-DU-6392	LGG	TCGA	SLEAVEVPSM	DEG_COP1_1	0.3056
p.A1291V	DO22237	LGG	ICGC	SLEAVEVPSM	DEG_COP1_1	0.3056
p.D1285N	DO225366	BRCA	ICGC	SLEAVEVPSM	DEG_COP1_1	0.1389
p.L1293V	DO233830	GACA	ICGC	SLEAVEVPSM	DEG_COP1_1	0.5654
p.S1304F	DO228322	MALY	ICGC	SLEAVEVPSM	DEG_COP1_1	0.25
p.G1306S	DO232761	PBCA	ICGC	SLEAVEVPSM	DEG_COP1_1	0.1944
p.S1292A	SIDM00929	Chondrosarcoma	GDSC	SLEAVEVPSM	DEG_COP1_1	0.7588
p.S1292A	SIDM00721	Small Cell Lung Carcinoma	GDSC	SLEAVEVPSM	DEG_COP1_1	0.7588
p.S1311F	SIDM01753	Gastric Carcinoma	GDSC	SLEAVEVPSM	DEG_COP1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_COP1_1	1292:1301	SLEAVEVPSM	COP1	0.929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons