DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SCF_FBW7_2

Location: 1510:1515

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 122.8

COIL: 0.9515

CONS_SCORE: 0.4334

DSS_SCORE: 0.7344

HELIX: 0.0428

FCONS_SCORE: 1.0071

RIG_SCORE: 0.6357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1501L	TCGA-05-4397	LUAD	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.5278
p.S1501L	DO25320	LUAD	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.5278
p.C1509Y	TCGA-22-5473	LUSC	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.3056
p.C1509Y	DO26467	LUSC	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.3056
p.T1511I	TCGA-4A-A93Y	KIRP	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.8189
p.T1511I	DO219690	KIRP	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.8189
p.E1515Q	TCGA-BT-A3PH	BLCA	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.6744
p.E1515Q	DO856	BLCA	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.6744
p.S1501A	TCGA-DF-A2KU	UCEC	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.5278
p.S1501A	DO223286	UCEC	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.5278
p.S1517I	TCGA-DX-A6YV	SARC	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.7222
p.S1517I	DO220011	SARC	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.7222
p.L1505P	TCGA-UZ-A9PO	KIRP	TCGA	LTPQRE	DEG_SCF_FBW7_2	0.1944
p.L1505P	DO219704	KIRP	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.1944
p.G1518R	DO233888	GACA	ICGC	LTPQRE	DEG_SCF_FBW7_2	0.25
p.N1506I	SIDM00860	Head and Neck Carcinoma	GDSC	LTPQRE	DEG_SCF_FBW7_2	0.2222
p.N1506H	FADU	upper_aerodigestive_tract	COSMIC	LTPQRE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SCF_FBW7_2	1510:1515	LTPQRE	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons