DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SCF_FBW7_2

Location: 1206:1212

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 126.0143

COIL: 0.9757

CONS_SCORE: 0.408

DSS_SCORE: 0.7429

HELIX: 0.0166

FCONS_SCORE: 1.0666

RIG_SCORE: 0.6414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1208S	TCGA-2Y-A9GY	LIHC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	0.8227
p.T1208S	DO219515	LIHC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	0.8227
p.L1200M	TCGA-91-6835	LUAD	TCGA	LRTPPRE	DEG_SCF_FBW7_2	0.1667
p.L1200M	DO26082	LUAD	ICGC	LRTPPRE	DEG_SCF_FBW7_2	0.1667
p.E1212Q	TCGA-CN-4723	HNSC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	0.6744
p.E1212Q	DO14830	HNSC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	0.6744
p.R1207S	TCGA-DD-AAEK	LIHC	TCGA	LRTPPRE	DEG_SCF_FBW7_2	0.6316
p.R1207S	DO52273	LIHC	ICGC	LRTPPRE	DEG_SCF_FBW7_2	0.6316
p.S1199L	DO225266	BRCA	ICGC	LRTPPRE	DEG_SCF_FBW7_2	0.5833
p.G1217V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LRTPPRE	DEG_SCF_FBW7_2	0.1944
p.G1217V	ACH-001364	Lung Cancer	CCLE	LRTPPRE	DEG_SCF_FBW7_2	0.1944
p.G1217V	NCI-H345	lung	COSMIC	LRTPPRE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SCF_FBW7_2	1206:1212	LRTPPRE	FBXW7	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons