DegronMD - O60271(SPAG9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1185C	TCGA-A5-A0G2	UCEC	TCGA	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.1944
p.T1249M	TCGA-AA-3864	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.1667
p.T1249M	TCGA-WS-AB45	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.1667
p.T1246M	TCGA-AP-A0LM	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.25
p.T1246M	TCGA-EC-A24G	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.25
p.R1185H	TCGA-CG-4460	STAD	TCGA	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.1944
p.P289L	TCGA-D6-6516	HNSC	TCGA	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation altering degron motif	0.6471
p.R176I	TCGA-DF-A2KU	UCEC	TCGA	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation altering degron motif	0.8102
p.R176I	DO223286	UCEC	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation altering degron motif	0.8102
p.K295N	TCGA-EO-A3B0	UCEC	TCGA	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation altering degron motif	0.5806
p.E1196Q	TCGA-ET-A3BV	THCA	TCGA	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.3056
p.E165K	TCGA-XF-A9SM	BLCA	TCGA	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation rewiring degron network	0.0556
p.E165K	DO223597	BLCA	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation rewiring degron network	0.0556
p.I1197T	DO49755	BLCA	ICGC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.2778
p.T1239M	DO51734	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.7423
p.T1239M	DO8490	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.7423
p.A1203V	DO7801	COAD	ICGC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.1111
p.K281N	DO222769	COCA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation rewiring degron network	0.1111
p.K281N	DO219773	UCEC	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation rewiring degron network	0.1111
p.Q306K	DO228948	LICA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation rewiring degron network	0.0556
p.A293E	DO229019	LICA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation altering degron motif	0.7701
p.P1198L	DO37477	SKCM	ICGC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.25
p.G1240C	DO229259	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.76
p.Q1253R	DO229216	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.0556
p.G184A	DO229218	THCA	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation rewiring degron network	0.3056
p.E1186Q	DO38921	THCA	ICGC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.2222
p.T1236M	DO40996	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.25
p.T1236M	DO43306	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.25
p.F1196C	DO43306	UCEC	ICGC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.3056
p.A1253V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.0556
p.A1253V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.0556
p.A1253V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.0556
p.S190A	SIDM00845	Burkitt's Lymphoma	GDSC	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation blocking phosphorylation signal	0.5833
p.S283L	SIDM00097	Breast Carcinoma	GDSC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation blocking phosphorylation signal	0.6111
p.S283L	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation blocking phosphorylation signal	0.6111
p.E298K	ACH-000783	Breast Cancer	CCLE	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation rewiring degron network	0.2778
p.E298K	CAMA-1	breast	COSMIC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation rewiring degron network	0.2778
p.A1239V	ACH-000995	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.6936
p.A1239V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.6936
p.H1200Y	ACH-000995	Leukemia	CCLE	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation substituting flanking lysine	0.3056
p.H1200Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation substituting flanking lysine	0.3056
p.G1247R	ACH-001622	Brain Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.2222
p.A293S	ACH-002143	Skin Cancer	CCLE	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation altering degron motif	0.7588
p.A293S	IST-MEL1	skin	COSMIC	PTDTPLKE	DEG_SCF_FBW7_2	289:296	Mutation altering degron motif	0.7588
p.H1204Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.0833
p.S190F	CAL-78	bone	COSMIC	ERTKLHQLS	DEG_APCC_DBOX_1	175:183	Mutation blocking phosphorylation signal	0.5833
p.H1205Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	1190:1195	Mutation rewiring degron network	0.0556
p.A1244V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation rewiring degron network	0.3056
p.A1243V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	1239:1243	Mutation altering degron motif	0.6936

Kaplan plot for SPAG9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG9

UniProt ID: O60271

Entrez ID: 9043

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG9 in