DegronMD

Uniprot ID: O60271

Source protein: C-Jun-amino-terminal kinase-interacting protein 4

Source gene: SPAG9

Class: LIG_APCC_ABBA_1

Location: 1190:1195

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5069

ASA_SCORE: 61.7167

COIL: 0.4955

CONS_SCORE: 0.3709

DSS_SCORE: 0.4916

HELIX: 0.0245

FCONS_SCORE: 1.0383

RIG_SCORE: 0.7822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1185C	TCGA-A5-A0G2	UCEC	TCGA	IRVYGD	LIG_APCC_ABBA_1	0.1944
p.R1185H	TCGA-CG-4460	STAD	TCGA	IRVYGD	LIG_APCC_ABBA_1	0.1944
p.E1196Q	TCGA-ET-A3BV	THCA	TCGA	IRVYGD	LIG_APCC_ABBA_1	0.3056
p.I1197T	DO49755	BLCA	ICGC	IRVYGD	LIG_APCC_ABBA_1	0.2778
p.A1203V	DO7801	COAD	ICGC	IRVYGD	LIG_APCC_ABBA_1	0.1111
p.P1198L	DO37477	SKCM	ICGC	IRVYGD	LIG_APCC_ABBA_1	0.25
p.E1186Q	DO38921	THCA	ICGC	IRVYGD	LIG_APCC_ABBA_1	0.2222
p.F1196C	DO43306	UCEC	ICGC	IRVYGD	LIG_APCC_ABBA_1	0.3056
p.H1200Y	ACH-000995	Leukemia	CCLE	IRVYGD	LIG_APCC_ABBA_1	0.3056
p.H1200Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	0.3056
p.H1204Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	0.0833
p.H1205Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IRVYGD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60271	C-Jun-amino-terminal kinase-interacting protein 4	LIG_APCC_ABBA_1	1190:1195	IRVYGD	APC,CDC20,FZR1	0.5069	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons