DegronMD

Uniprot ID: O60271

Source protein: C-Jun-amino-terminal kinase-interacting protein 4

Source gene: SPAG9

Class: DEG_SCF_FBW7_2

Location: 289:296

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 93.1875

COIL: 0.8431

CONS_SCORE: 0.2949

DSS_SCORE: 0.5885

HELIX: 0.1261

FCONS_SCORE: 1.1129

RIG_SCORE: 0.7364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P289L	TCGA-D6-6516	HNSC	TCGA	PTDTPLKE	DEG_SCF_FBW7_2	0.6471
p.K295N	TCGA-EO-A3B0	UCEC	TCGA	PTDTPLKE	DEG_SCF_FBW7_2	0.5806
p.K281N	DO222769	COCA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	0.1111
p.K281N	DO219773	UCEC	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	0.1111
p.Q306K	DO228948	LICA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	0.0556
p.A293E	DO229019	LICA	ICGC	PTDTPLKE	DEG_SCF_FBW7_2	0.7701
p.S283L	SIDM00097	Breast Carcinoma	GDSC	PTDTPLKE	DEG_SCF_FBW7_2	0.6111
p.S283L	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTDTPLKE	DEG_SCF_FBW7_2	0.6111
p.E298K	ACH-000783	Breast Cancer	CCLE	PTDTPLKE	DEG_SCF_FBW7_2	0.2778
p.E298K	CAMA-1	breast	COSMIC	PTDTPLKE	DEG_SCF_FBW7_2	0.2778
p.A293S	ACH-002143	Skin Cancer	CCLE	PTDTPLKE	DEG_SCF_FBW7_2	0.7588
p.A293S	IST-MEL1	skin	COSMIC	PTDTPLKE	DEG_SCF_FBW7_2	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60271	C-Jun-amino-terminal kinase-interacting protein 4	DEG_SCF_FBW7_2	289:296	PTDTPLKE	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons