DegronMD

Uniprot ID: O60271

Source protein: C-Jun-amino-terminal kinase-interacting protein 4

Source gene: SPAG9

Class: DEG_APCC_DBOX_1

Location: 175:183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7756

ASA_SCORE: 100.5222

COIL: 0.3021

CONS_SCORE: 0.381

DSS_SCORE: 0.5111

HELIX: 0.689

FCONS_SCORE: 1.0342

RIG_SCORE: 0.724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R176I	TCGA-DF-A2KU	UCEC	TCGA	ERTKLHQLS	DEG_APCC_DBOX_1	0.8102
p.R176I	DO223286	UCEC	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	0.8102
p.E165K	TCGA-XF-A9SM	BLCA	TCGA	ERTKLHQLS	DEG_APCC_DBOX_1	0.0556
p.E165K	DO223597	BLCA	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	0.0556
p.G184A	DO229218	THCA	ICGC	ERTKLHQLS	DEG_APCC_DBOX_1	0.3056
p.S190A	SIDM00845	Burkitt's Lymphoma	GDSC	ERTKLHQLS	DEG_APCC_DBOX_1	0.5833
p.S190F	CAL-78	bone	COSMIC	ERTKLHQLS	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60271	C-Jun-amino-terminal kinase-interacting protein 4	DEG_APCC_DBOX_1	175:183	ERTKLHQLS	APC,CDC20,FZR1	0.7756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons