DegronMD - Q02930(CREB5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S140Y	TCGA-3A-A9IZ	PAAD	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.712
p.N128K	TCGA-49-4506	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.D503Y	TCGA-55-6712	LUAD	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6214
p.R152L	TCGA-55-7907	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.P136L	TCGA-AA-3693	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.P136L	TCGA-EO-A22U	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.P136L	ACH-001451	Cervical Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.S495I	TCGA-AP-A059	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1944
p.S495I	TCGA-AP-A059	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.P506L	TCGA-BS-A0UF	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.6471
p.P138L	TCGA-D3-A8GI	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7582
p.A134V	TCGA-E6-A2P9	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2222
p.D503N	TCGA-EO-A22R	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.5821
p.G490E	TCGA-FD-A43U	BLCA	TCGA	VGSST	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.6087
p.S482F	TCGA-VQ-A8P2	STAD	TCGA	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1389
p.V143D	TCGA-ZF-A9RM	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.V136D	DO219079	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.G483E	DO645	BLCA	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.R494K	DO218173	BRCA	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.1667
p.R494K	DO218173	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.P129L	DO9330	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.P129L	DO43755	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.P149H	DO233245	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1389
p.S134I	DO233903	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2222
p.S134I	DO229031	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2222
p.R145L	DO229019	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145L	DO229025	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145L	DO25396	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.A140S	DO229025	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7588
p.R145S	DO231788	LINC	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.D496Y	DO25310	LUAD	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222
p.D496Y	DO25310	LUAD	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.25
p.S133Y	DO218961	PAAD	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1944
p.P131L	DO50284	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1389
p.P499L	DO41488	UCEC	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.P499L	DO41488	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.D496N	DO42713	UCEC	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.2222
p.D496N	DO42713	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.25
p.S488I	DO41361	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.T150N	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.T150N	ACH-000496	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.T150N	NCI-H1792	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.R152H	SIDM00040	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	SIDM00245	Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	SIDM00217	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	SIDM00045	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	KYSE-150	oesophagus	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	TMK-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	MS-1	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.R152H	HSC-39	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.V489I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7076
p.P506S	SIDM00140	Melanoma	GDSC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.5641
p.P506S	ACH-000968	Skin Cancer	CCLE	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.5641
p.P506S	COLO-792	skin	COSMIC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation altering degron motif	0.5641
p.M135I	SIDM00217	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.M135I	ACH-000999	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.M135I	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.S137L	ACH-001557	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.75
p.R145H	HSC-39	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145H	TMK-1	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145H	MS-1	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145H	KYSE-150	oesophagus	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.R145H	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.25
p.Q143H	COR-L32	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.H140Y	HCT-15	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7229
p.M128I	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.T143N	NCI-H1792	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.P139L	SNU-1040	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7582
p.Q129R	PCI-30	upper aerodigestive tract	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.P499S	COLO-792	skin	COSMIC	HRTDLNPIL	DEG_APCC_DBOX_1	500:508	Mutation rewiring degron network	0.3056
p.P499S	COLO-792	skin	COSMIC	VGSST	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.P151S	MCC26	skin	COSMIC	PQSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREB5

UniProt ID: Q02930

Entrez ID: 9586

Protein name: Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREB5 in