DegronMD

Uniprot ID: Q02930

Source protein: Cyclic AMP-responsive element-binding protein 5

Source gene: CREB5

Class: DEG_APCC_DBOX_1

Location: 500:508

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.658

ASA_SCORE: 99.6333

COIL: 0.7247

CONS_SCORE: 0.3199

DSS_SCORE: 0.6926

HELIX: 0.1913

FCONS_SCORE: 1.0275

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D503Y	TCGA-55-6712	LUAD	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	0.6214
p.S495I	TCGA-AP-A059	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	0.1944
p.P506L	TCGA-BS-A0UF	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	0.6471
p.D503N	TCGA-EO-A22R	UCEC	TCGA	HRTDLNPIL	DEG_APCC_DBOX_1	0.5821
p.R494K	DO218173	BRCA	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	0.1667
p.D496Y	DO25310	LUAD	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	0.2222
p.P499L	DO41488	UCEC	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	0.3056
p.D496N	DO42713	UCEC	ICGC	HRTDLNPIL	DEG_APCC_DBOX_1	0.2222
p.P506S	SIDM00140	Melanoma	GDSC	HRTDLNPIL	DEG_APCC_DBOX_1	0.5641
p.P506S	ACH-000968	Skin Cancer	CCLE	HRTDLNPIL	DEG_APCC_DBOX_1	0.5641
p.P506S	COLO-792	skin	COSMIC	HRTDLNPIL	DEG_APCC_DBOX_1	0.5641
p.P499S	COLO-792	skin	COSMIC	HRTDLNPIL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_APCC_DBOX_1	500:508	HRTDLNPIL	APC,CDC20,FZR1	0.658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons