DegronMD

Uniprot ID: Q5TCM9

Source protein: Late cornified envelope protein 5A

Source gene: LCE5A

Class: DEG_SPOP_SBC_1

Location: 82:86

E3 ligase: SPOP

DEGRON score: 0.798

ASA_SCORE: 90.1

COIL: 0.9374

CONS_SCORE: 0.5038

DSS_SCORE: 0.3537

HELIX: 0.0432

FCONS_SCORE: 0.9428

RIG_SCORE: 0.6284

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S84I	DO229036	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.7341
p.S86I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	0.7341
p.S86I	ACH-000981	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	0.7341
p.S86I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	0.7341
p.R81Q	TCGA-AN-A0AK	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	0.3056
p.R81Q	DO1608	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.3056
p.R81L	DO229018	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	0.3056
p.R80H	TCGA-FI-A2D0	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.2778
p.R80H	DO43891	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.R80S	TCGA-NJ-A4YQ	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	0.2778
p.R80S	DO218944	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	0.2778
p.G89V	TCGA-A5-A0G2	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.G89V	DO41235	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	TCGA-AP-A1DV	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	TCGA-E6-A1LX	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	TCGA-EO-A22X	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	TCGA-FG-7638	LGG	TCGA	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	DO41020	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	DO43186	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.25
p.R79Q	DO43907	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.25
p.S90N	TCGA-EO-A3KX	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	0.2222
p.S90N	DO219774	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	0.2222
p.S77F	TCGA-EB-A5UM	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	0.1944
p.S77F	DO47282	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	0.1944
p.Q76L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	0.1667

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Drug responses associated with LCE5A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PQSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	DEG_SPOP_SBC_1	887:891	PQSSS	SPOP	0.997	More...
Q2TAZ0	Autophagy-related protein 2 homolog A	DEG_SPOP_SBC_1	742:746	PQSSS	SPOP	0.9683	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	60:64	PQSSS	SPOP	0.674	More...
Q9BWV1	Brother of CDO	DEG_SPOP_SBC_1	592:596	PQSSS	SPOP	0.7123	More...
O60271	C-Jun-amino-terminal kinase-interacting protein 4	DEG_SPOP_SBC_1	1239:1243	PQSSS	SPOP	0.9213	More...
Q6UY09	Carcinoembryonic antigen-related cell adhesion molecule 20	DEG_SPOP_SBC_1	438:442	PQSSS	SPOP	0.8914	More...
Q02930	Cyclic AMP-responsive element-binding protein 5	DEG_SPOP_SBC_1	138:142	PQSSS	SPOP	0.9993	More...
Q8TDM6	Disks large homolog 5	DEG_SPOP_SBC_1	797:801	PQSSS	SPOP	0.9776	More...
Q8NHY3	GAS2-like protein 2	DEG_SPOP_SBC_1	384:388	PQSSS	SPOP	0.9783	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	519:523	PQSSS	SPOP	0.9325	More...
Q5TCM9	Late cornified envelope protein 5A	DEG_SPOP_SBC_1	82:86	PQSSS	SPOP	0.798	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	477:481	PQSSS	SPOP	0.9239	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	83:87	PQSSS	SPOP	0.8965	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	299:303	PQSSS	SPOP	0.8349	More...
P49023	Paxillin	DEG_SPOP_SBC_1	81:85	PQSSS	SPOP	0.9894	More...
F5H4B4	Protein FAM227A	DEG_SPOP_SBC_1	345:349	PQSSS	SPOP	0.9381	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	739:743	PQSSS	SPOP	0.9901	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	1117:1121	PQSSS	SPOP	0.9855	More...
P0CB48	Putative upstream-binding factor 1-like protein 6	DEG_SPOP_SBC_1	332:336	PQSSS	SPOP	0.5892	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	99:103	PQSSS	SPOP	0.9292	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	129:133	PQSSS	SPOP	0.9781	More...
Q9UNW9	RNA-binding protein Nova-2	DEG_SPOP_SBC_1	204:208	PQSSS	SPOP	0.9633	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	322:326	PQSSS	SPOP	0.9692	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	413:417	PQSSS	SPOP	0.9895	More...
O95835	Serine/threonine-protein kinase LATS1	DEG_SPOP_SBC_1	434:438	PQSSS	SPOP	0.9911	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSSS

Degron related mutations and impact score

Drug responses associated with LCE5A mutations

All proteins holding degron of PQSSS