DegronMD - O95835(LATS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V25F	TCGA-22-4613	LUSC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.V25F	DO26468	LUSC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.P44L	TCGA-56-8503	LUSC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.P44L	DO45444	LUSC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.S45Y	TCGA-AX-A0J1	UCEC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0556
p.S45Y	DO41199	UCEC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0556
p.A380S	TCGA-AX-A2HC	UCEC	TCGA	PPPY	ITCH	373:376	Mutation rewiring degron network	0.2222
p.A380S	DO41572	UCEC	ICGC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.2222
p.R28Q	TCGA-B0-5710	KIRC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7329
p.R28Q	DO16308	KIRC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7329
p.Y376C	TCGA-B5-A3FA	UCEC	TCGA	PPPY	ITCH	373:376	Mutation altering degron motif	0.7087
p.Y376C	DO52402	UCEC	ICGC	PPPY	ITCH	373:376	Mutation altering degron motif	0.7087
p.P375S	TCGA-BA-6869	HNSC	TCGA	PPPY	ITCH	373:376	Mutation altering degron motif	0.5641
p.P375S	DO14250	HNSC	ICGC	PPPY	ITCH	373:376	Mutation altering degron motif	0.5641
p.G554E	TCGA-BP-4989	KIRC	TCGA	PPPY	ITCH	556:559	Mutation rewiring degron network	0.2778
p.G554E	DO17313	KIRC	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.2778
p.P445L	TCGA-BR-A4QL	STAD	TCGA	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.P445L	DO233245	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.P445L	DO38723	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.R35W	TCGA-BT-A3PJ	BLCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7523
p.R35W	DO44097	BLCA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7523
p.R35W	SIDM01588	Endometrial Carcinoma	GDSC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7523
p.R35W	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7523
p.E36D	TCGA-C8-A26V	BRCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.3056
p.E36D	DO4287	BRCA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.3056
p.S444P	TCGA-CG-5721	STAD	TCGA	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.S444P	DO38192	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.A549S	TCGA-CG-5733	STAD	TCGA	PPPY	ITCH	556:559	Mutation rewiring degron network	0.1389
p.A549S	DO38551	STAD	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.1389
p.P568L	TCGA-EE-A29L	SKCM	TCGA	PPPY	ITCH	556:559	Mutation rewiring degron network	0.0833
p.P568L	DO222599	MELA	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.0833
p.P568L	DO37835	SKCM	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.0833
p.Q553E	TCGA-EK-A2H0	CESC	TCGA	PPPY	ITCH	556:559	Mutation rewiring degron network	0.25
p.Q553E	DO49020	CESC	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.25
p.A365T	TCGA-EO-A3B0	UCEC	TCGA	PPPY	ITCH	373:376	Mutation rewiring degron network	0.1111
p.A365T	DO219773	UCEC	ICGC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.1111
p.T367I	TCGA-FP-7829	STAD	TCGA	PPPY	ITCH	373:376	Mutation rewiring degron network	0.1667
p.T367I	DO38308	STAD	ICGC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.1667
p.Q442K	TCGA-K4-A5RJ	BLCA	TCGA	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.Q442K	DO49784	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.R28W	TCGA-V5-A7RB	ESCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.8634
p.A439T	DO222451	BTCA	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.A439T	DO229375	BTCA	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.T17N	DO229019	LICA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation blocking phosphorylation signal	0.5
p.P374T	DO229015	LICA	ICGC	PPPY	ITCH	373:376	Mutation altering degron motif	0.7031
p.Q553K	DO229032	LICA	ICGC	PPPY	ITCH	556:559	Mutation rewiring degron network	0.25
p.R35Q	DO229061	LICA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6218
p.M30I	DO231587	LINC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6507
p.S446R	DO34945	PACA	ICGC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1111
p.P373Q	SIDM00948	Burkitt's Lymphoma	GDSC	PPPY	ITCH	373:376	Mutation altering degron motif	0.7035
p.P373Q	DG-75	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	373:376	Mutation altering degron motif	0.7035
p.R370W	SIDM00539	Esophageal Carcinoma	GDSC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.25
p.P377S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.P377S	ACH-000855	Esophageal Cancer	CCLE	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.P377S	KYSE-150	oesophagus	COSMIC	PPPY	ITCH	373:376	Mutation rewiring degron network	0.3056
p.P434R	SIDM01042	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7512
p.P434R	ACH-001065	Breast Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7512
p.P434R	EVSA-T	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7512
p.P558R	ACH-001525	Cervical Cancer	CCLE	PPPY	ITCH	556:559	Mutation altering degron motif	0.6401

Kaplan plot for LATS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LATS1

UniProt ID: O95835

Entrez ID: 9113

Protein name: Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LATS1 in