DegronMD

Uniprot ID: O95835

Source protein: Serine/threonine-protein kinase LATS1

Source gene: LATS1

Class: DEG_APCC_DBOX_1

Location: 27:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9101

ASA_SCORE: 61.9444

COIL: 0.0404

CONS_SCORE: 0.4384

DSS_SCORE: 0.5349

HELIX: 0.9563

FCONS_SCORE: 1.0697

RIG_SCORE: 0.7701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V25F	TCGA-22-4613	LUSC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.2778
p.V25F	DO26468	LUSC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.2778
p.P44L	TCGA-56-8503	LUSC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.0833
p.P44L	DO45444	LUSC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.0833
p.S45Y	TCGA-AX-A0J1	UCEC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.0556
p.S45Y	DO41199	UCEC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.0556
p.R28Q	TCGA-B0-5710	KIRC	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.7329
p.R28Q	DO16308	KIRC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.7329
p.R35W	TCGA-BT-A3PJ	BLCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.7523
p.R35W	DO44097	BLCA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.7523
p.R35W	SIDM01588	Endometrial Carcinoma	GDSC	SRQMLQEIR	DEG_APCC_DBOX_1	0.7523
p.R35W	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRQMLQEIR	DEG_APCC_DBOX_1	0.7523
p.E36D	TCGA-C8-A26V	BRCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.3056
p.E36D	DO4287	BRCA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.3056
p.R28W	TCGA-V5-A7RB	ESCA	TCGA	SRQMLQEIR	DEG_APCC_DBOX_1	0.8634
p.T17N	DO229019	LICA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.5
p.R35Q	DO229061	LICA	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.6218
p.M30I	DO231587	LINC	ICGC	SRQMLQEIR	DEG_APCC_DBOX_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95835	Serine/threonine-protein kinase LATS1	DEG_APCC_DBOX_1	27:35	SRQMLQEIR	APC,CDC20,FZR1	0.9101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons