DegronMD - Q8NHY3(GAS2L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T523I	TCGA-CC-A123	LIHC	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1944
p.T523I	DO23038	LIHC	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1944
p.I505N	TCGA-CG-5717	STAD	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1389
p.I505N	DO38272	STAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1389
p.T514K	TCGA-DA-A3F8	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.7306
p.T514K	DO37418	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.7306
p.R511C	TCGA-EB-A6QZ	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.R511C	DO48626	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.G516E	TCGA-EE-A20C	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.6087
p.G516E	DO222775	MELA	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.6087
p.G516E	DO47665	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.6087
p.R511H	TCGA-HC-7211	PRAD	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.R511H	DO36287	PRAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.S518R	TCGA-L5-A4OE	ESCA	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.7427
p.T523S	TCGA-NC-A5HT	LUSC	TCGA	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1944
p.T523S	DO219205	LUSC	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1944
p.Q390P	DO234231	ESAD	ICGC	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2778
p.R506W	DO234353	ESAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1667
p.S386T	DO46873	RECA	ICGC	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.6005
p.R506Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1667
p.R506Q	ACH-000521	Lung Cancer	CCLE	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1667
p.G392D	SIDM00781	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.G392D	SIDM00780	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.G392D	ACH-000967	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.G392D	ACH-001199	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.P509S	SIDM00531	Pancreatic Carcinoma	GDSC	PPTPGRS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.25

Kaplan plot for GAS2L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAS2L2

UniProt ID: Q8NHY3

Entrez ID: 246176

Protein name: GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAS2L2 in